| pubmed-article:8826970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1261381 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C1527362 | lld:lifeskim |
| pubmed-article:8826970 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:8826970 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8826970 | pubmed:dateCreated | 1996-11-4 | lld:pubmed |
| pubmed-article:8826970 | pubmed:abstractText | Syngeneic pancreatic islet grafts in diabetic NOD mice are infiltrated by mononuclear leukocytes, beta-cells are selectively destroyed, and autoimmune diabetes recurs. This model was used to identify islet graft-infiltrating mononuclear leukocytes associated with beta-cell destruction and diabetes recurrence. We compared cell surface antigen and cytokine-producing phenotypes of mononuclear leukocytes in islet grafts from NOD mice that were protected from diabetes recurrence by complete Freund's adjuvant (CFA) administration (beta-cell nondestructive insulitis) and in islet grafts from control phosphate-buffered saline (PBS)-injected NOD mice (beta-cell destructive insulitis). Islet grafts from CFA-injected mice contained fewer CD4+ and CD8+ cells and more B cells; also fewer interferon gamma (IFN-gamma), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-alpha)-positive cells and more IL-4 and IL-10 positive cells. By performing two-color immunostaining of cell surface antigens and intracellular IFN-gamma, we found that IFN-gamma positive cells in islet grafts from CFA- and PBS-injected mice were approximately equally divided between CD4+ and CD8+ T-cell subsets. Also, the frequencies of both CD4+ IFN-gamma + and CD8+ IFN-gamma + cells were decreased in islet grafts from CFA-injected mice. These findings suggest that destruction of beta-cells in syngeneic islets transplanted into NOD mice is promoted by cells producing Th1-type cytokines (IFN-gamma, IL-2, and TNF-alpha) and prevented by cells producing TH2-type cytokines (IL-4 and IL-10). Furthermore, both CD4+ and CD8+ IFN-gamma-producing T-cells in the islet grafts appear to be involved in beta-cell destruction and diabetes recurrence. | lld:pubmed |
| pubmed-article:8826970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8826970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8826970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8826970 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8826970 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:8826970 | pubmed:author | pubmed-author:RabinovitchAA | lld:pubmed |
| pubmed-article:8826970 | pubmed:author | pubmed-author:MosmannT RTR | lld:pubmed |
| pubmed-article:8826970 | pubmed:author | pubmed-author:RajotteR VRV | lld:pubmed |
| pubmed-article:8826970 | pubmed:author | pubmed-author:Suarez-Pinzon... | lld:pubmed |
| pubmed-article:8826970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8826970 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8826970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8826970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8826970 | pubmed:pagination | 1350-7 | lld:pubmed |
| pubmed-article:8826970 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8826970 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8826970 | pubmed:articleTitle | Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction. | lld:pubmed |
| pubmed-article:8826970 | pubmed:affiliation | Department of Medicine, University of Alberta, Edmonton, Canada. | lld:pubmed |
| pubmed-article:8826970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8826970 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8826970 | lld:pubmed |
