| pubmed-article:8816826 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8816826 | lifeskim:mentions | umls-concept:C0056373 | lld:lifeskim |
| pubmed-article:8816826 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:8816826 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:8816826 | pubmed:dateCreated | 1996-11-13 | lld:pubmed |
| pubmed-article:8816826 | pubmed:abstractText | Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526 antagonizes the stimulatory effects of exogenous CRF on plasma ACTH, locus coeruleus neuronal firing and startle response amplitude. Potential anxiolytic activity of CP-154,526 was revealed in a fearpotentiated startle paradigm. These data are presented in the context of clinical findings, which suggest that CRF is hypersecreted in certain pathological states. We propose that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders. | lld:pubmed |
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| pubmed-article:8816826 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8816826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8816826 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8816826 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8816826 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8816826 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:CollinsJJ | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:BraseltonJ... | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:SeegerTT | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:SchulzD WDW | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:SeymourPP | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:HeymJJ | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:SchmidtA WAW | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:FaraciSS | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:ChenY LYL | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:SprouseJJ | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:MansbachR SRS | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:DunaiskisAA | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:TingleyF... | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:CormanMM | lld:pubmed |
| pubmed-article:8816826 | pubmed:author | pubmed-author:WinstonE NEN | lld:pubmed |
| pubmed-article:8816826 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8816826 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:8816826 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8816826 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8816826 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8816826 | pubmed:pagination | 10477-82 | lld:pubmed |
| pubmed-article:8816826 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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