| pubmed-article:8806806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0019733 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0108779 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:8806806 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:8806806 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8806806 | pubmed:dateCreated | 1996-11-1 | lld:pubmed |
| pubmed-article:8806806 | pubmed:abstractText | The in vitro cytotoxic response to human melanoma is characterized by CD3+ CD8+ T-cells which recognize shared peptide antigens presented in the context of HLA class-I-encoded gene products. We report here studies of a CD3+, CD4+, CD8-, HLA-A2-restricted, melanoma-specific cytotoxic T-cell clone derived by limiting dilution from a T-cell line induced in PBLs from a melanoma patient following in vitro stimulation with an HLA-A2-matched melanoma cell line. The CD4+ cytotoxic T-cell clone is lytic only for melanomas which share the HLA-A2 allele, and the cytotoxicity is blocked by antibody to the T-cell receptor and by antibody to HLA class I. The clone proliferates only following stimulation with HLA-A2-matched melanoma tumor cells. The data suggest that cytotoxic CD4+ T-cells may play a significant role in immunity to melanoma, and HLA class-I-restricted recognition of melanoma may not necessarily require the CD8 molecule on the lytic T-cell. | lld:pubmed |
| pubmed-article:8806806 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8806806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8806806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8806806 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8806806 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8806806 | pubmed:author | pubmed-author:SeiglerH FHF | lld:pubmed |
| pubmed-article:8806806 | pubmed:author | pubmed-author:Quinn-AllenM... | lld:pubmed |
| pubmed-article:8806806 | pubmed:author | pubmed-author:DarrowT LTL | lld:pubmed |
| pubmed-article:8806806 | pubmed:author | pubmed-author:Abdel-WahabZZ | lld:pubmed |
| pubmed-article:8806806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8806806 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8806806 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:8806806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8806806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8806806 | pubmed:pagination | 52-9 | lld:pubmed |
| pubmed-article:8806806 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:meshHeading | pubmed-meshheading:8806806-... | lld:pubmed |
| pubmed-article:8806806 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8806806 | pubmed:articleTitle | Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2. | lld:pubmed |
| pubmed-article:8806806 | pubmed:affiliation | Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. | lld:pubmed |
| pubmed-article:8806806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8806806 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8806806 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8806806 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8806806 | lld:pubmed |
