| pubmed-article:8806053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0332853 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0086140 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0015376 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:8806053 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8806053 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8806053 | pubmed:dateCreated | 1997-3-3 | lld:pubmed |
| pubmed-article:8806053 | pubmed:abstractText | A new tissue repair agent, RGTA11, is described for its ability to enhance colonic anastomosis repair and resistance to leakage. RGTA11 is a dextran derivative containing 110% carboxymethyl groups, 2.6% carboxymethyl benzylamide groups, and 36.6% carboxymethyl benzylamide sulfonate groups. RGTA11 was deemed efficient to protect the heparin-binding growth factors FGF2 against trypsin digestion. By this property RGTA11 mimicked heparin or heparan sulfate. We have also found that RGTA11 protected TGF beta 1 against trypsin digestion while heparin did not. RGTA11 was then tested in an in vivo wound-healing model of colonic anastomosis. Our results indicate that after 48 h, RGTA11- or RGTA11/FGF-2-treated animals presented a resistance of the anastomosis to leakage which was increased twofold (p < 0.05) over untreated controls. After 96 h and until day 7 there was no more difference with control animals. Our results suggest that RGTA11 presents potential clinical interest by preventing earlier leakage of colonic anastomosis. | lld:pubmed |
| pubmed-article:8806053 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8806053 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8806053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8806053 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8806053 | pubmed:issn | 0021-9304 | lld:pubmed |
| pubmed-article:8806053 | pubmed:author | pubmed-author:BenoitJJ | lld:pubmed |
| pubmed-article:8806053 | pubmed:author | pubmed-author:BarritaultDD | lld:pubmed |
| pubmed-article:8806053 | pubmed:author | pubmed-author:SézeurAA | lld:pubmed |
| pubmed-article:8806053 | pubmed:author | pubmed-author:AyoubNN | lld:pubmed |
| pubmed-article:8806053 | pubmed:author | pubmed-author:MeddahiAA | lld:pubmed |
| pubmed-article:8806053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8806053 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:8806053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8806053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8806053 | pubmed:pagination | 293-7 | lld:pubmed |
| pubmed-article:8806053 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8806053 | pubmed:meshHeading | pubmed-meshheading:8806053-... | lld:pubmed |
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| pubmed-article:8806053 | pubmed:meshHeading | pubmed-meshheading:8806053-... | lld:pubmed |
| pubmed-article:8806053 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8806053 | pubmed:articleTitle | Heparin-like polymers derived from dextran enhance colonic anastomosis resistance to leakage. | lld:pubmed |
| pubmed-article:8806053 | pubmed:affiliation | Laboratoire de Recherche sur la Croissance, la Réparation et la Régénération Tissulaire (CRRET), CNRS URA 1813, Université Paris XII-Val de Marne, Créteil, France. | lld:pubmed |
| pubmed-article:8806053 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8806053 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8806053 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8806053 | lld:pubmed |
