| pubmed-article:8799136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C1138842 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C0080113 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:8799136 | lifeskim:mentions | umls-concept:C1335532 | lld:lifeskim |
| pubmed-article:8799136 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:8799136 | pubmed:dateCreated | 1996-10-31 | lld:pubmed |
| pubmed-article:8799136 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8799136 | pubmed:abstractText | Retinoblastoma (RB-1) is a tumor suppressor gene that encodes a 105-kDa nuclear phosphoprotein. To date, RB genes have been isolated only from metazoans. We have isolated a cDNA from maize endosperm whose predicted protein product (ZmRb) shows homology to the "pocket" A and B domains of the Rb protein family. We found ZmRb behaves as a pocket protein based on its ability to specifically interact with oncoproteins encoded by DNA tumor viruses (E7, T-Ag, E1A). ZmRb can interact in vitro and in vivo with the replication-associated protein, RepA, encoded by the wheat dwarf virus. The maize Rb-related protein undergoes changes in level and phosphorylation state concomitant with endoreduplication, and it is phosphorylated in vitro by an S-phase kinase from endoreduplicating endosperm cells. Together, our results suggest that ZmRb is a representative of the pocket protein family and may play a role in cell cycle progression. Moreover, certain plant monopartite geminiviruses may operate similarly to mammalian DNA viruses, by targeting and inactivating the retinoblastoma protein, which otherwise induces G1 arrest. | lld:pubmed |
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| pubmed-article:8799136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8799136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8799136 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8799136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8799136 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8799136 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:LarkinsB ABA | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:HelentjarisTT | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:GraffHH | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:BurnettR JRJ | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:DeCaprioJ AJA | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:KaelinW GWGJr | lld:pubmed |
| pubmed-article:8799136 | pubmed:author | pubmed-author:SellersW RWR | lld:pubmed |
| pubmed-article:8799136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8799136 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8799136 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8799136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8799136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8799136 | pubmed:pagination | 8962-7 | lld:pubmed |
| pubmed-article:8799136 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:8799136 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8799136 | pubmed:articleTitle | A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. | lld:pubmed |
| pubmed-article:8799136 | pubmed:affiliation | Department of Plant Sciences, University of Arizona, Tucson 85721, USA. | lld:pubmed |
| pubmed-article:8799136 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8799136 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8799136 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8799136 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
