| pubmed-article:8779966 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0017136 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0020452 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8779966 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8779966 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:8779966 | pubmed:dateCreated | 1996-12-20 | lld:pubmed |
| pubmed-article:8779966 | pubmed:abstractText | This study was performed to identify the possible neural mechanisms and mediators that underlie the gastric mucosal hyperemia evoked by cholecystokinin octapeptide (CCK-8). Gastric mucosal blood flow in anesthetized rats was assessed by the clearance of hydrogen and gastric acid secretion determined in the luminally perfused stomach. The gastric mucosal hyperemic effect of a low dose of CCK-8 (0.04 nmol/min iv infusion for 7 min) was abolished by inhibition of nitric oxide synthesis with NG-nitro-L-arginine methyl ester (15 mg/kg iv) and significantly blunted by defunctionalization of afferent neurons with a neurotoxic dose of capsaicin (125 mg/kg sc). The hyperemic reaction to a high dose of CCK-8 (0.2 nmol/min) was not significantly affected by these pharmacological maneuvers. The vasodilator response to low-dose CCK-8 (0.04 nmol/min) was further analyzed and found to be inhibited by acute bilateral subdiaphragmatic vagotomy, atropine (1 mumol/kg ip), and the antagonistic calcitonin gene-related peptide (CGRP) fragment CGRP-(8-37) (6 nmol/ min ia). Cyclooxygenase inhibition with indomethacin (10 mg/kg ip) was ineffective. The CCK-8-induced increment of gastric acid secretion was not significantly altered by any of these procedures. These results indicate that the gastric vasodilator effect of submaximal doses of CCK-8 is brought about by a vagovagal reflex that involves acetylcholine, CGRP or a related peptide, and nitric oxide as vasodilator messengers. | lld:pubmed |
| pubmed-article:8779966 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8779966 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8779966 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8779966 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8779966 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8779966 | pubmed:author | pubmed-author:PeskarB MBM | lld:pubmed |
| pubmed-article:8779966 | pubmed:author | pubmed-author:HolzerPP | lld:pubmed |
| pubmed-article:8779966 | pubmed:author | pubmed-author:HeinemannAA | lld:pubmed |
| pubmed-article:8779966 | pubmed:author | pubmed-author:JocicMM | lld:pubmed |
| pubmed-article:8779966 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8779966 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:8779966 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8779966 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8779966 | pubmed:pagination | G253-8 | lld:pubmed |
| pubmed-article:8779966 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8779966 | pubmed:meshHeading | pubmed-meshheading:8779966-... | lld:pubmed |
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| pubmed-article:8779966 | pubmed:meshHeading | pubmed-meshheading:8779966-... | lld:pubmed |
| pubmed-article:8779966 | pubmed:meshHeading | pubmed-meshheading:8779966-... | lld:pubmed |
| pubmed-article:8779966 | pubmed:meshHeading | pubmed-meshheading:8779966-... | lld:pubmed |
| pubmed-article:8779966 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8779966 | pubmed:articleTitle | CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide. | lld:pubmed |
| pubmed-article:8779966 | pubmed:affiliation | Department of Experimental and Clinical Pharmacology, University of Graz, Austria. | lld:pubmed |
| pubmed-article:8779966 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8779966 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
