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pubmed-article:8778873pubmed:abstractTextThe effects of hypertension and REM sleep deprivation on spontaneous and postsigh apneas have been studied in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats by simultaneously monitoring their respiration and sleep by the EEG. The amount of REM and non-REM sleep in SHR rats was identical to WKY rats under control as well as REM sleep-deprived recording conditions. Hypertension was associated with an increase in postsigh apneas, as was evident by the increased postsigh apnea index in non-REM and total sleep in SHR rats when compared to normotensive WKY rats. In contrast, REM sleep deprivation suppressed the postsigh apnea expression both in non-REM and total sleep in SHR rats. The incidence of spontaneous apneas was increased by a combination of hypertension and REM sleep deprivation, as was shown in REM-deprived SHR rats, while each of these conditions alone had no effect on spontaneous apneas. These results suggest a role for hypertension in the postsigh apnea genesis and the existence of partially distinct mechanisms for the two types of apneas.lld:pubmed
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pubmed-article:8778873pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8778873pubmed:articleTitleSleep apnea in normal and REM sleep-deprived normotensive Wistar-Kyoto and spontaneously hypertensive (SHR) rats.lld:pubmed
pubmed-article:8778873pubmed:affiliationDepartment of Pharmacology, College of Medicine, University of Illinois at Chicago 60612, USA.lld:pubmed
pubmed-article:8778873pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8778873pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8778873pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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