| pubmed-article:8776725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8776725 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:8776725 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8776725 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8776725 | pubmed:abstractText | GH and PRL stimulate both proliferation and insulin production in pancreatic beta-cells as well as in the rat insulinoma cell line RIN-5AH, We report here that human GH increases insulin mRNA levels in RIN-5AH cells via both somatogenic and lactogenic receptors. GH stimulated the rat insulin 1 promoter activity 2-fold, and this stimulation was abolished by introduction of a block mutation in a gamma-interferon-activated sequence (GAS)-like element (GLE) with the sequence 5'-TTCTGGGAA-3' located in the rat insulin 1 enhancer at position -330 to -322. This element, termed Ins-GLE, was able to confer GH responsiveness to a heterologous promoter. GH induced the binding of two protein complexes to the Ins-GLE. An antibody directed against the transcription factor STAT5 (signal transducer and activator of transcription) supershifted the GH-induced complexes. Furthermore, in COS7 cells transiently transfected with STAT5 and GH receptor cDNAs, it was found that expression of STAT5 was necessary for GH induction of these two DNA-binding complexes. These results suggest that GH stimulates insulin 1 promoter activity by inducing the binding of STAT5 to Ins-GLE. | lld:pubmed |
| pubmed-article:8776725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8776725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8776725 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8776725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8776725 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8776725 | pubmed:issn | 0888-8809 | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:NielsenJ HJH | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:GronerBB | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:GouilleuxFF | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:SerupPP | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:BillestrupNN | lld:pubmed |
| pubmed-article:8776725 | pubmed:author | pubmed-author:GalsgaardE... | lld:pubmed |
| pubmed-article:8776725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8776725 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8776725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8776725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8776725 | pubmed:pagination | 652-60 | lld:pubmed |
| pubmed-article:8776725 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8776725 | pubmed:meshHeading | pubmed-meshheading:8776725-... | lld:pubmed |
| pubmed-article:8776725 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8776725 | pubmed:articleTitle | Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene. | lld:pubmed |
| pubmed-article:8776725 | pubmed:affiliation | Hagedom Research Institute, Gentofte, Denmark. | lld:pubmed |
| pubmed-article:8776725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8776725 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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