| pubmed-article:8770589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C0027922 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C1519618 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8770589 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8770589 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8770589 | pubmed:dateCreated | 1996-10-23 | lld:pubmed |
| pubmed-article:8770589 | pubmed:abstractText | The Neurospora crassa arg-2 gene encodes the small subunit of arginine-specific carbamoyl phosphate synthetase. The levels of arg-2 mRNA and mRNA translation are negatively regulated by arginine. An upstream open reading frame (uORF) in the transcript's 5' region has been implicated in arginine-specific control. An arg-2-hph fusion gene encoding hygromycin phosphotransferase conferred arginine-regulated resistance to hygromycin when introduced into N. crassa. We used an arg-2-hph strain to select for UV-induced mutants that grew in the presence of hygromycin and arginine, and we isolated 46 mutants that had either of two phenotypes. One phenotype indicated altered expression of both arg-2-hph and arg-2 genes; the other, altered expression of arg-2-hph but not arg-2. One of the latter mutations, which was genetically closely linked to arg-2-hph, was recovered from the 5' region of the arg-2-hph gene using PCR. Sequence analyses and transformation experiments revealed a mutation at uORF codon 12 (Asp to Asn) that abrogated negative regulation. Examination of the distribution of ribosomes on arg-2-hph transcripts showed that loss of regulation had a translational component, indicating the uORF sequence was important for Arg-specific translational control. Comparisons with other uORF5 suggest common elements in translational control mechanisms. | lld:pubmed |
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| pubmed-article:8770589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8770589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770589 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8770589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8770589 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8770589 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:8770589 | pubmed:author | pubmed-author:FreitagMM | lld:pubmed |
| pubmed-article:8770589 | pubmed:author | pubmed-author:SachsM SMS | lld:pubmed |
| pubmed-article:8770589 | pubmed:author | pubmed-author:DighdeNN | lld:pubmed |
| pubmed-article:8770589 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8770589 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:8770589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8770589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8770589 | pubmed:pagination | 117-27 | lld:pubmed |
| pubmed-article:8770589 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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