| pubmed-article:8770203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8770203 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:8770203 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
| pubmed-article:8770203 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:8770203 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:8770203 | lifeskim:mentions | umls-concept:C1705492 | lld:lifeskim |
| pubmed-article:8770203 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8770203 | pubmed:dateCreated | 1996-10-22 | lld:pubmed |
| pubmed-article:8770203 | pubmed:abstractText | We present here a maximal likelihood algorithm for estimating single-channel kinetic parameters from idealized patch-clamp data. The algorithm takes into account missed events caused by limited time resolution of the recording system. Assuming a fixed dead time, we derive an explicit expression for the corrected transition rate matrix by generalizing the theory of Roux and Sauve (1985, Biophys. J. 48:149-158) to the case of multiple conductance levels. We use a variable metric optimizer with analytical derivatives for rapidly maximizing the likelihood. The algorithm is applicable to data containing substates and multiple identical or nonidentical channels. It allows multiple data sets obtained under different experimental conditions, e.g., concentration, voltage, and force, to be fit simultaneously. It also permits a variety of constraints on rate constants and provides standard errors for all estimates of model parameters. The algorithm has been tested extensively on a variety of kinetic models with both simulated and experimental data. It is very efficient and robust; rate constants for a multistate model can often be extracted in a processing time of approximately 1 min, largely independent of the starting values. | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8770203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8770203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8770203 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8770203 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:8770203 | pubmed:author | pubmed-author:AuerbachAA | lld:pubmed |
| pubmed-article:8770203 | pubmed:author | pubmed-author:SachsFF | lld:pubmed |
| pubmed-article:8770203 | pubmed:author | pubmed-author:QinFF | lld:pubmed |
| pubmed-article:8770203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8770203 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8770203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8770203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8770203 | pubmed:pagination | 264-80 | lld:pubmed |
| pubmed-article:8770203 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:meshHeading | pubmed-meshheading:8770203-... | lld:pubmed |
| pubmed-article:8770203 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8770203 | pubmed:articleTitle | Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. | lld:pubmed |
| pubmed-article:8770203 | pubmed:affiliation | Department of Biophysical Sciences, State University of New York at Buffalo, New York 14214, USA. qin@acsu.buffalo.edu | lld:pubmed |
| pubmed-article:8770203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8770203 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8770203 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8770203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770203 | lld:pubmed |
