| pubmed-article:8769943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8769943 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:8769943 | lifeskim:mentions | umls-concept:C0002823 | lld:lifeskim |
| pubmed-article:8769943 | lifeskim:mentions | umls-concept:C0199176 | lld:lifeskim |
| pubmed-article:8769943 | lifeskim:mentions | umls-concept:C0063083 | lld:lifeskim |
| pubmed-article:8769943 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:8769943 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8769943 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8769943 | pubmed:abstractText | The objective of this investigation was to evaluate the effect of ancrod, a fibrinogenolytic protease from Malayan pit viper venom, locally delivered through a photopolymerized biodegradable hydrogel in preventing postoperative adhesions. The experimental model involved ischemic and serosal injury to the uterine horns of rats with measurement of adhesions 7 days after injury. Ancrod was delivered intravenously for 5 days preoperatively through 3 days postoperatively, intraperitoneally for 5 days preoperatively, intraperitoneally for 3 days postoperatively, and locally via the hydrogel formed upon the uterine horns by photopolymerization of an aqueous precursor solution. Systemic defibrinogenation by intravenous administration pre-through postoperatively reduced the extent of adhesions by 63% without dose sensitivity from 5 to 20 units/kg/day. Preoperative defibrinogenation by intraperitoneal administration reduced adhesion extent by up to 57%, while postoperative administration was more effective, reducing adhesions by up to 84% with a dose-dependent response from 5 to 20 units/kg/day. Administration of ancrod by local release from a tissue-adherent hydrogel was more effective than either the hydrogel alone or the same amount of ancrod administered by postoperative intraperitoneal injection. Adhesions were reduced by 82% at a local dose of 10 units/kg, compared to a reduction of 68% due to the barrier properties of the gel alone (P < 0.01) and of 19% due to the same amount of drug given at the time of surgery (P < 0.001). Local delivery of ancrod from a tissue-adherent hydrogel barrier thus provided an efficacious prevention to postoperative adhesions while permitting administration of a low total dose of the protease. | lld:pubmed |
| pubmed-article:8769943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8769943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8769943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8769943 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8769943 | pubmed:issn | 0022-4804 | lld:pubmed |
| pubmed-article:8769943 | pubmed:author | pubmed-author:HubbellJ AJA | lld:pubmed |
| pubmed-article:8769943 | pubmed:author | pubmed-author:ChowdhuryS... | lld:pubmed |
| pubmed-article:8769943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8769943 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8769943 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8769943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8769943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8769943 | pubmed:pagination | 58-64 | lld:pubmed |
| pubmed-article:8769943 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8769943 | pubmed:meshHeading | pubmed-meshheading:8769943-... | lld:pubmed |
| pubmed-article:8769943 | pubmed:meshHeading | pubmed-meshheading:8769943-... | lld:pubmed |
| pubmed-article:8769943 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8769943 | pubmed:articleTitle | Adhesion prevention with ancrod released via a tissue-adherent hydrogel. | lld:pubmed |
| pubmed-article:8769943 | pubmed:affiliation | Department of Chemical Engineering, University of Texas, Austin 78712, USA. | lld:pubmed |
| pubmed-article:8769943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8769943 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8769943 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769943 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769943 | lld:pubmed |
