Linked Life Data

8766552

Source:http://linkedlifedata.com/resource/pubmed/id/8766552

Statements in which the resource exists.
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pubmed-article:8766552pubmed:abstractTextWe report on a soluble (s) form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that is spontaneously released by B and T lymphocytes. Immunoprecipitation with anti-CD21 mAb of culture supernatants of surface and biosynthetically labeled B and T cell lines revealed a single band with an apparent molecular mass of 135 kDa. The molecule exhibited a molecular mass 10 kDa lower than that of membrane CD21. The release of soluble CD21 (sCD21) was time dependent and correlated with a parallel decrease in the expression of the membrane-associated molecule. The protein was also found in culture supernatants of tonsillar B cells and normal human thymocytes. Epitopic analysis using combinations of anti-CD21 monoclonal antibodies (mAb) indicated that sCD21 and membrane CD21 were similarly recognized by mAb directed against short consensus repeats (SCR) 1-2, SCR 4-5 and SCR 9-11. Affinity-purified sCD21 was capable of binding to purified human iC3b and to human recombinant CD23, as assessed by enzyme-linked immunosorbent assay and by using the BIAcore technology. In addition, normal human serum was found to contain a soluble form of CD21 that exhibited a similar molecular mass to that of the molecule shed by B and T cells in culture. The serum form of CD21 was recognized by all anti-CD21 mAb that we tested and showed a high reactivity with mAb directed against SCR 1-2. Our observations suggest that B and T cells shed the extracellular portion of CD21 and release a soluble molecule that retains the ligand-binding properties of CD21, thus having a potential role in immunoregulation.lld:pubmed
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pubmed-article:8766552pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8766552pubmed:articleTitleHuman lymphocytes shed a soluble form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that binds iC3b and CD23.lld:pubmed
pubmed-article:8766552pubmed:affiliationINSERM U430, Hôpital Broussais, Paris, France.lld:pubmed
pubmed-article:8766552pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8766552pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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