| pubmed-article:8761182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0025677 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0021488 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:8761182 | lifeskim:mentions | umls-concept:C0522529 | lld:lifeskim |
| pubmed-article:8761182 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8761182 | pubmed:dateCreated | 1996-9-25 | lld:pubmed |
| pubmed-article:8761182 | pubmed:abstractText | In this study, we sought to determine whether liposomal preparations containing a phospholipid conjugate of methotrexate and dimyristoylphosphatidylethanolamine (MTX-gamma-DMPE) incorporated within their lipid membranes are effective in suppressing established joint inflammation in a monoarticular model of arthritis in the rat. Arthritis was induced in the right knee joint of Lewis rats. The rats were treated with a single intra-articular injection of either free methotrexate (MTX), liposomal MTX [MTX-multilamellar vesicles (MLV)-1.2 microns or MTX-small unilamellar vesicles (SUV)-100 nm], control liposomes (E-LIPO) or saline into the inflamed knee 7 days after arthritis induction. There was no significant difference in knee swelling in MTX-, saline- and E-LIPO-treated rats up to 21 days after treatment. However, MTX-MLV treatment produced a significant reduction in knee swelling (26.5 +/- 6.0%: mean +/- S.E.M.) 1 day after intra-articular injection compared with MTX (3.5 +/- 3.5%) and MTX-SUV (14.4 +/- 2.4%), respectively. Over the next 20 days, knee swelling in MTX-MLV-treated rats fell progressively and almost returned to normal. MTX-MLV treatment also inhibited the cellular infiltration associated with the arthritis. Large multilamellar liposomal preparations of MTX-gamma-DMPE are more effective than free MTX and MTX-SUV in suppressing inflammation. Their differential effects in treating the antigen-induced arthritis model are related to their retention within the joint space. | lld:pubmed |
| pubmed-article:8761182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8761182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8761182 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8761182 | pubmed:issn | 0263-7103 | lld:pubmed |
| pubmed-article:8761182 | pubmed:author | pubmed-author:CamilleriJ... | lld:pubmed |
| pubmed-article:8761182 | pubmed:author | pubmed-author:WilliamsB DBD | lld:pubmed |
| pubmed-article:8761182 | pubmed:author | pubmed-author:WilliamsA SAS | lld:pubmed |
| pubmed-article:8761182 | pubmed:author | pubmed-author:GoodfellowR... | lld:pubmed |
| pubmed-article:8761182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8761182 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:8761182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8761182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8761182 | pubmed:pagination | 719-24 | lld:pubmed |
| pubmed-article:8761182 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
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| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:meshHeading | pubmed-meshheading:8761182-... | lld:pubmed |
| pubmed-article:8761182 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8761182 | pubmed:articleTitle | A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis. | lld:pubmed |
| pubmed-article:8761182 | pubmed:affiliation | Rheumatology Research Laboratory, University of Wales College of Medicine, Heath Park, Cardiff. | lld:pubmed |
| pubmed-article:8761182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8761182 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8761182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8761182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8761182 | lld:pubmed |
