| pubmed-article:8760807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0230960 | lld:lifeskim |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0021081 | lld:lifeskim |
| pubmed-article:8760807 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8760807 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8760807 | pubmed:dateCreated | 1996-9-23 | lld:pubmed |
| pubmed-article:8760807 | pubmed:abstractText | The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors. Mononuclear cytotrophoblasts, the specialized fetal cells of the placenta that invade the uterus, play an important role. These cells express HLA-G, an unusual major histocompatibility complex class I-B molecule, and secrete cytokines and pregnancy-specific proteins that can regulate immune function. We investigated whether cytotrophoblasts secrete interleukin 10 (IL-10), a cytokine that potently inhibits alloresponses in mixed lymphocyte reactions. Cytotrophoblasts from all stages of pregnancy produced IL-10 in vitro, but neither placental fibroblasts nor choriocarcinoma (malignant trophoblast) cell lines did so. Spontaneous IL-10 production averaged 650, 853, and 992 pg/10(6) cells in the first, second, and third trimesters of pregnancy, respectively. IL-10 secretion dropped approximately 10-fold after the first 24 h of culture, and was paralleled by a decrease in messenger RNA. IL-10 messenger RNA was detected in biopsies of the placenta and the portion of the uterus that contains invasive cytotrophoblasts, suggesting that this cytokine is also produced in vivo. IL-10 secreted by cytotrophoblasts in vitro is bioactive, as determined by its ability to suppress interferon gamma production in an allogeneic mixed lymphocyte reaction. We conclude that human cytotrophoblast IL-10 may be an important factor that contributes to maternal tolerance of the allogeneic fetus. | lld:pubmed |
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| pubmed-article:8760807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8760807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8760807 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8760807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8760807 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8760807 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:RothII | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:FisherS JSJ | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:AbramsJ SJS | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:CorryD BDB | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:LocksleyR MRM | lld:pubmed |
| pubmed-article:8760807 | pubmed:author | pubmed-author:LittonM JMJ | lld:pubmed |
| pubmed-article:8760807 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8760807 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8760807 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8760807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8760807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8760807 | pubmed:pagination | 539-48 | lld:pubmed |
| pubmed-article:8760807 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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