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pubmed-article:8759904pubmed:abstractTextWe sought to gain perspective on platelet production in the fetus and the newborn by counting and characterizing megakaryocytes from available cord blood. Elutriation was used to isolate circulating megakaryocytes from umbilical arteries and veins obtained at scheduled caesarean sections of nine normal term fetuses. Megakaryocytes were identified by established criteria, their diameters measured, and maturation stages recorded. Large numbers of megakaryocytes, mostly mature, were found in both the umbilical arteries and veins, many times more than previously observed circulating in adult blood. In term infants more than a third of the mature megakaryocytes had unusually decreased nuclear lobation and were dwarf cells with diameters as small as 13 microns, which we considered to be micromegakaryocytes. The atypicality of these small but mature cells is seen as merely a leftward skewing in the development of megakaryocyte ploidies. We believe that in normal fetuses the extent of megakaryocyte ploidization and development is distinctive and probably regulated differently to the adult pattern.lld:pubmed
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pubmed-article:8759904pubmed:authorpubmed-author:LevineR FRFlld:pubmed
pubmed-article:8759904pubmed:authorpubmed-author:MillerM KMKlld:pubmed
pubmed-article:8759904pubmed:authorpubmed-author:OlsonT ATAlld:pubmed
pubmed-article:8759904pubmed:authorpubmed-author:WeismanL ELElld:pubmed
pubmed-article:8759904pubmed:authorpubmed-author:ShoffP KPKlld:pubmed
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pubmed-article:8759904pubmed:pagination391-9lld:pubmed
pubmed-article:8759904pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8759904pubmed:year1996lld:pubmed
pubmed-article:8759904pubmed:articleTitleMature micromegakaryocytes: an unusual developmental pattern in term infants.lld:pubmed
pubmed-article:8759904pubmed:affiliationDepartment of Veterans Affairs Medical Center, Washington, D.C. 20422, USA.lld:pubmed
pubmed-article:8759904pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8759904pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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