| pubmed-article:8757341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0003308 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C1880266 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0147226 | lld:lifeskim |
| pubmed-article:8757341 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8757341 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8757341 | pubmed:dateCreated | 1996-11-22 | lld:pubmed |
| pubmed-article:8757341 | pubmed:abstractText | TNF mediates multiple biologic activities through two distinct cell surface receptors, TNFR-p55 and TNFR-p75. TNF plays an important role in nonspecific resistance against the fungus Candida albicans. We used transgenic mice deficient for TNFR-p55 or TNFR-p75 to investigate the role of the TNFR in antifungal defense. Mice deficient for TNFR-p55 have highly impaired ability to clear infection with C. albicans and readily succumb to the infection. Also mice deficient for TNFR-p75 had a significant reduction in their ability to clear the fungus although lethality was not increased. These data demonstrate that TNFR-p55 in particular, but also TNFR-p75, plays a definite role in defense against infection with C. albicans. In NMRI mice, infection with C. albicans resulted in a significant systemic release of soluble (s)TNFR-p75. Cyclophosphamide-induced granulocytopenia led to a reduction of sTNFR-p75 release, whereas levels of bioactive TNF in response to fungal infection were increased. Release of sTNFR-p55 was not affected by induction of granulocytopenia. These observations suggest that granulocytes are a source of sTNFR-p75, possibly contributing to regulation of TNF activity during infection with C. albicans. | lld:pubmed |
| pubmed-article:8757341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8757341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757341 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8757341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8757341 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8757341 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:BuurmanW AWA | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:WaageAA | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:BergtGG | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:SteinshamnSS | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:BemelmansM... | lld:pubmed |
| pubmed-article:8757341 | pubmed:author | pubmed-author:van TitsL JLJ | lld:pubmed |
| pubmed-article:8757341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8757341 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8757341 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8757341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8757341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8757341 | pubmed:pagination | 2155-9 | lld:pubmed |
| pubmed-article:8757341 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8757341 | pubmed:meshHeading | pubmed-meshheading:8757341-... | lld:pubmed |
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| pubmed-article:8757341 | pubmed:meshHeading | pubmed-meshheading:8757341-... | lld:pubmed |
| pubmed-article:8757341 | pubmed:meshHeading | pubmed-meshheading:8757341-... | lld:pubmed |
| pubmed-article:8757341 | pubmed:meshHeading | pubmed-meshheading:8757341-... | lld:pubmed |
| pubmed-article:8757341 | pubmed:meshHeading | pubmed-meshheading:8757341-... | lld:pubmed |
| pubmed-article:8757341 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8757341 | pubmed:articleTitle | TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense. | lld:pubmed |
| pubmed-article:8757341 | pubmed:affiliation | Institute of Cancer Research and Molecular Biology, University Medical Center, Trondheim, Norway. | lld:pubmed |
| pubmed-article:8757341 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8757341 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21937 | entrezgene:pubmed | pubmed-article:8757341 | lld:entrezgene |
| entrez-gene:21938 | entrezgene:pubmed | pubmed-article:8757341 | lld:entrezgene |
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