Linked Life Data

8753648

Source:http://linkedlifedata.com/resource/pubmed/id/8753648

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pubmed-article:8753648pubmed:abstractTextThe AFG3 gene of Saccharomyces cerevisiae encodes a mitochondrial inner membrane protein with ATP-dependent protease activity. To gain more insight into the function of this protein, multi-copy suppressors of an afg3-null mutation were isolated. Three genes were found that restored partial growth on non-fermentable carbon sources, all of which affect the biogenesis of respiratory competent mitochondria: PIM1(LON) encodes a matrix-localized ATP-dependent protease involved in the turnover of matrix proteins; OXA1(PET1402) encodes a putative mitochondrial inner membrane protein involved in the biogenesis of the respiratory chain; and MBA1 encodes a mitochondrial protein required for optimal respiratory growth. All three genes also suppressed a null mutation in a related gene, RCA1, as well as in the combination of afg3- and rca1-null.lld:pubmed
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pubmed-article:8753648pubmed:articleTitleThree genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed.lld:pubmed
pubmed-article:8753648pubmed:affiliationDepartment of Molecular Cell Biology, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, The Netherlands.lld:pubmed
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