| pubmed-article:8752917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0221284 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0282587 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C1334863 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8752917 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8752917 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8752917 | pubmed:dateCreated | 1996-11-7 | lld:pubmed |
| pubmed-article:8752917 | pubmed:abstractText | CD56 is a member of the neural cell adhesion molecule family expressed on cells of the central nervous system and also on NK cells. Previous studies suggest the involvement of CD56 in effector-to-target cell conjugation mediated by NK cells. It was shown recently that CD56 is also expressed by subpopulations of CD8+ and CD4+ T cells. The present study describes the functional characteristics of CD4+CD56+ T cell lines established from blood of multiple sclerosis patients by stimulation with myelin basic protein (MBP). CD4+CD56+, MBP-specific T cell lines were able to lyse MBP-pulsed target cells in an HLA class II-restricted fashion. At the same time, they mediated MHC-unrestricted lysis of CD56+ target cells such as CD56+ lymphoid or glial tumor cells, but not of the typical NK target, K562. A number of experimental results including separation of CD4+CD56+ T cells into CD56 high and low expressing populations, cold target inhibition, as well as killing of CD56-transfected cells indicate that homotypic CD56 interactions are involved in the MHC-unrestricted lysis. CD56 interactions are not sufficient but are required for effector/target interaction. Our findings raise the possibility that CD4+CD56+ T cells sharing properties of both typical Ag-specific Th0-like T cells and NK cells might be involved in damage of tissues expressing CD56/neural cell adhesion molecule, such as the central nervous system. Thus, we provide evidence for a novel mechanism that could lead to organ-specific autoreactivity. | lld:pubmed |
| pubmed-article:8752917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8752917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8752917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8752917 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8752917 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:MartinRR | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:LORR | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:McFarlandHH | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:Dhib-JalbutSS | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:van NoortJ... | lld:pubmed |
| pubmed-article:8752917 | pubmed:author | pubmed-author:VergelliMM | lld:pubmed |
| pubmed-article:8752917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8752917 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8752917 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8752917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8752917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8752917 | pubmed:pagination | 679-88 | lld:pubmed |
| pubmed-article:8752917 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:meshHeading | pubmed-meshheading:8752917-... | lld:pubmed |
| pubmed-article:8752917 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8752917 | pubmed:articleTitle | A novel population of CD4+CD56+ myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule. | lld:pubmed |
| pubmed-article:8752917 | pubmed:affiliation | Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:8752917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8752917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8752917 | lld:pubmed |
