| pubmed-article:8750915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8750915 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8750915 | lifeskim:mentions | umls-concept:C1706968 | lld:lifeskim |
| pubmed-article:8750915 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8750915 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8750915 | pubmed:dateCreated | 1996-11-6 | lld:pubmed |
| pubmed-article:8750915 | pubmed:abstractText | The effects of bivalent lead on ion channels activated by kainate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA) were studied using Xenopus oocytes microinjected with mRNA from rat brain. Lead reduced kainate-induced membrane currents in a reversible and dose-dependent manner, without affecting membrane currents induced by AMPA. Lead decreased the kainate currents with a concentration of 0.1 micromol/1 to 0.93 +/- 0.01 and with a concentration of 100 micromol/1 to 0.41 +/- 0.04 of the control values. The blocking effect of lead on kainate responses was voltage dependent. The inhibition was strongest at -90 mV to -70 mV and became weaker at more positive membrane potentials. The effect of lead on the kainate-induced membrane currents remained unchanged when the concentration of kainate was increased. Hence lead probably represents a noncompetitive channel-blocking agent for non-N-methyl-D-aspartate (NMDA) receptor channels activated by kainate. | lld:pubmed |
| pubmed-article:8750915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8750915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8750915 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8750915 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:8750915 | pubmed:author | pubmed-author:SpeckmannE... | lld:pubmed |
| pubmed-article:8750915 | pubmed:author | pubmed-author:WittingUU | lld:pubmed |
| pubmed-article:8750915 | pubmed:author | pubmed-author:MusshoffUU | lld:pubmed |
| pubmed-article:8750915 | pubmed:author | pubmed-author:MadejaMM | lld:pubmed |
| pubmed-article:8750915 | pubmed:author | pubmed-author:BindingNN | lld:pubmed |
| pubmed-article:8750915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8750915 | pubmed:volume | 353 | lld:pubmed |
| pubmed-article:8750915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8750915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8750915 | pubmed:pagination | 42-5 | lld:pubmed |
| pubmed-article:8750915 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:meshHeading | pubmed-meshheading:8750915-... | lld:pubmed |
| pubmed-article:8750915 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8750915 | pubmed:articleTitle | Lead-induced blockage of kainate-sensitive receptor channels. | lld:pubmed |
| pubmed-article:8750915 | pubmed:affiliation | Institut fur Physiologie, Münster, Germany. | lld:pubmed |
| pubmed-article:8750915 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8750915 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8750915 | lld:pubmed |
