| pubmed-article:8750761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8750761 | lifeskim:mentions | umls-concept:C1832073 | lld:lifeskim |
| pubmed-article:8750761 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8750761 | pubmed:dateCreated | 1996-10-10 | lld:pubmed |
| pubmed-article:8750761 | pubmed:abstractText | The effects of insulin on renal haemodynamics and renal sodium handling were studied in eight insulin-dependent (type 1) diabetic patients (aged 30 +/- 3 years). Seven healthy men (aged 38 +/- 4 years) served as controls. The type 1 diabetic patients were resistant to insulin-stimulated glucose disposal as estimated by a 45% lower metabolic (P < 0.01) clearance of glucose as compared with controls. However, type 1 diabetic patients were still sensitive to the distal tubular antinatriuretic effect of insulin, as indicated by an increase in distal sodium reabsorption (95.5 +/- 0.5% to 96.9% +/- 0.4%; P < 0.05) during insulin infusion compared with controls (95.5% +/- 0.6% to 97.4% +/- 0.3%; P < 0.05). In control subjects insulin infusion was associated with 9% increases (P < 0.05) in lithium clearance and in renal plasma flow, whereas no significant increases in lithium clearance and in renal plasma flow were observed in the type 1 diabetic patients. In both groups, the changes in renal plasma flow in response to insulin infusion were positively correlated with that in lithium clearance (r = 0.80 and r = 0.90, respectively; P < 0.05-0.01). In conclusion, the present result demonstrates an intact distal tubular sodium retaining effect in conjunction with a blunted decrease in proximal tubular sodium reabsorption following insulin infusion, which could be the result of an impaired renal vasodilation in type 1 diabetes mellitus. | lld:pubmed |
| pubmed-article:8750761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8750761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750761 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8750761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8750761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8750761 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8750761 | pubmed:issn | 0940-5429 | lld:pubmed |
| pubmed-article:8750761 | pubmed:author | pubmed-author:AlvestrandAA | lld:pubmed |
| pubmed-article:8750761 | pubmed:author | pubmed-author:BolinderJJ | lld:pubmed |
| pubmed-article:8750761 | pubmed:author | pubmed-author:StenvinkelPP | lld:pubmed |
| pubmed-article:8750761 | pubmed:author | pubmed-author:Ottosson-Seeb... | lld:pubmed |
| pubmed-article:8750761 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8750761 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:8750761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8750761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8750761 | pubmed:pagination | 230-4 | lld:pubmed |
| pubmed-article:8750761 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:meshHeading | pubmed-meshheading:8750761-... | lld:pubmed |
| pubmed-article:8750761 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8750761 | pubmed:articleTitle | Effect of insulin on renal sodium handling and renal haemodynamics in insulin-dependent (type 1) diabetes mellitus patients. | lld:pubmed |
| pubmed-article:8750761 | pubmed:affiliation | Department of Renal Medicine Huddinge University Hospital, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:8750761 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8750761 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8750761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
