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pubmed-article:8745345pubmed:abstractTextWe found that the expression of sulphonylurea receptors which control ATP-dependent potassium channels was up-regulated both by a receptor agonist and by potassium channel activators. Sulphonylurea receptors detected on cell membranes of cultured chick cardiomyocytes by [3H]glibenclamide were increased 2.8-fold following growth of the cells for 1-2 days in the presence of 30 nM glibenclamide. [3H]glibenclamide binding was also increased approximately 2-fold following growth of the cells in the presence of the ATP-dependent potassium channel activators, pinacidil, minoxidil and diazoxide, but was diminished to 75% of control following treatment with depolarizing concentrations of KCl.lld:pubmed
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pubmed-article:8745345pubmed:articleTitleRegulation of glibenclamide receptors in cultured chick cardiomyocytes.lld:pubmed
pubmed-article:8745345pubmed:affiliationDepartment of Biochemical Pharmacology, State University of New York at Buffalo 14260, USA.lld:pubmed
pubmed-article:8745345pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8745345pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed