| pubmed-article:8741871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8741871 | lifeskim:mentions | umls-concept:C0041429 | lld:lifeskim |
| pubmed-article:8741871 | lifeskim:mentions | umls-concept:C0220761 | lld:lifeskim |
| pubmed-article:8741871 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:8741871 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:8741871 | lifeskim:mentions | umls-concept:C0030761 | lld:lifeskim |
| pubmed-article:8741871 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8741871 | pubmed:dateCreated | 1996-10-21 | lld:pubmed |
| pubmed-article:8741871 | pubmed:abstractText | The inheritance of spontaneous dizygotic (DZ) twinning was investigated in 1,422 three-generation pedigrees ascertained through mothers of spontaneous DZ proband twins. DZ twinning was modelled as a trait expressed only in women. The penetrance was modelled first as a parity independent and secondly as parity dependent. The observed frequencies of maternal and paternal grandmothers with DZ twins differed significantly from the expectations under an X-linked mode of inheritance. Complex segregation analysis showed that the parity-independent phenotype of "having DZ twins" was consistent with an autosomal monogenic dominant model, with a gene frequency of 0.035 and a female-specific lifetime penetrance of 0.10. Recessive, polygenic, and sporadic models were rejected. The autosomal dominant model revealed a strong robustness against a changing population prevalence and the loss of information due to the presence of same-sexed twin pairs of unknown zygosity. When DZ twinning was modelled as a parity dependent trait, the data were compatible with an autosomal dominant model with a gene frequency of 0.306 and a penetrance of 0.03 per birth for female gene carriers. | lld:pubmed |
| pubmed-article:8741871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8741871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8741871 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8741871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8741871 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8741871 | pubmed:issn | 0148-7299 | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:LewisC MCM | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:Van den... | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:VlietinckR... | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:OrlebekeJ FJF | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:BoomsmaD IDI | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:DawesT OTO | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:DeromR MRM | lld:pubmed |
| pubmed-article:8741871 | pubmed:author | pubmed-author:MeulemansW... | lld:pubmed |
| pubmed-article:8741871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8741871 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:8741871 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8741871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8741871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8741871 | pubmed:pagination | 258-63 | lld:pubmed |
| pubmed-article:8741871 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:meshHeading | pubmed-meshheading:8741871-... | lld:pubmed |
| pubmed-article:8741871 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8741871 | pubmed:articleTitle | Genetic modelling of dizygotic twinning in pedigrees of spontaneous dizygotic twins. | lld:pubmed |
| pubmed-article:8741871 | pubmed:affiliation | Center for Human Genetics, Catholic University of Leuven, Belgium. | lld:pubmed |
| pubmed-article:8741871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8741871 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:8741871 | pubmed:publicationType | Twin Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8741871 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8741871 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8741871 | lld:pubmed |
