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pubmed-article:8735659pubmed:abstractTextBladder growth was induced by partial urethral obstruction. Bladder hypertrophy was evident at 53 h after obstruction and continued over a 6 weeks period. Small bladder arteries were taken from fixed anatomical locations of the bladder circulation, mounted in a small vessel myograph and the optimal diameter for maximal isometric force development was determined (Lmax K+ = 125 mM stimulation). Bladder hypertrophy was associated with an enlarged Lmax from 53h onward (compared with sham-operated controls) and Lmax continued to increase until 10 days after urethral obstruction. Between 10 days and 6 weeks no further increase of the diameter was observed. Increased diameters in vitro were accompanied by a transiently increased [3H] Thymidine uptake in the small arteries which peaked at 53 h after obstruction but was still above background at 10 days. At this time point, small arterial growth was associated with a significant relative increase in the M isoform of LDH as determined with agarose electrophoresis on tissue homogenates. Thus organ growth induced small vessel growth in the rat is characterized by a rapid onset, increased but transient DNA-turnover and LDH-isoform changes. The latter mimic changes seen in other types of smooth muscle growth.lld:pubmed
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pubmed-article:8735659pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8735659pubmed:articleTitleGrowth resistance-sized arteries in response to bladder hypertrophy in the rat: time-course, DNA-synthesis and LDH-isoform pattern.lld:pubmed
pubmed-article:8735659pubmed:affiliationDepartment of Physiology and Neuroscience, Lund University, Sweden.lld:pubmed
pubmed-article:8735659pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8735659pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed