| pubmed-article:8732291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0600531 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0065042 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:8732291 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8732291 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8732291 | pubmed:dateCreated | 1997-2-13 | lld:pubmed |
| pubmed-article:8732291 | pubmed:abstractText | 1. Induction of lipocortin 1 secretion by dexamethasone has been demonstrated, although the secretory mechanism is still unknown. We have studied the effects of 12-tetradecanoyl phorbol 13-acetate (TPA) and/or dexamethasone on the expression, translocation, and secretion of lipocortin 1 in U937 cells. 2. The expression of lipocortin 1 and its mRNA increased during TPA-induced differentiation of U937 cells to a maximum of 1.9 fold and 8.2 fold, respectively, after 48 h. Both the protein and the mRNA levels decreased after 48 h. 3. TPA caused the translocation of lipocortin 1 from the cytosol to the membrane of U937 cells in a time-dependent manner, as determined by Western blot analysis. The translocation was concurrent with the differentiation of the cells. After 48 h of TPA treatment, 82.6 +/- 6.5% of lipocortin 1 was present in the membrane fraction compared to 41.6 +/- 1.7% in untreated cells. 4. The amount of lipocortin 1 that was externally bound (associated) with the membrane increased to 3.2 fold as the cytosol to membrane translocation of lipocortin 1 increased. 5. Dexamethasone decreased the externally bound lipocortin 1, but had no effect on the cytosol to membrane translocation. 6. This offers a model system with which the function and the secretion mechanism of lipocortin 1 can be studied. Our data is consistent with the hypothesis that the secretory mechanism is through an unknown pathway, involving the translocation of lipocortin 1 from the cytosol to the internal membranes, and then, its secretion to the external membrane. | lld:pubmed |
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| pubmed-article:8732291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8732291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8732291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8732291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8732291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8732291 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8732291 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:8732291 | pubmed:author | pubmed-author:ChoY JYJ | lld:pubmed |
| pubmed-article:8732291 | pubmed:author | pubmed-author:MoonH BHB | lld:pubmed |
| pubmed-article:8732291 | pubmed:author | pubmed-author:KangS ASA | lld:pubmed |
| pubmed-article:8732291 | pubmed:author | pubmed-author:NaD SDS | lld:pubmed |
| pubmed-article:8732291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8732291 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:8732291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8732291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8732291 | pubmed:pagination | 1780-4 | lld:pubmed |
| pubmed-article:8732291 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
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| pubmed-article:8732291 | pubmed:meshHeading | pubmed-meshheading:8732291-... | lld:pubmed |
| pubmed-article:8732291 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8732291 | pubmed:articleTitle | Translocation of lipocortin (annexin) 1 to the membrane of U937 cells induced by phorbol ester, but not by dexamethasone. | lld:pubmed |
| pubmed-article:8732291 | pubmed:affiliation | Department of Biochemistry, University of Ulsan, Seoul, Korea. | lld:pubmed |
| pubmed-article:8732291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8732291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8732291 | lld:pubmed |
