| pubmed-article:8726960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0020676 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8726960 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:8726960 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8726960 | pubmed:dateCreated | 1996-11-7 | lld:pubmed |
| pubmed-article:8726960 | pubmed:abstractText | The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did not influence the lipid composition. There was a significant 2-fold increase of efficacy and 6-fold decrease of potency of carbachol-induced inositol phosphate (IP) accumulation in HO, with respect to control rats. The efficacy of trans-(1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD)-induced IP accumulation was also higher in HO (by 50%), without differences in EC50 values. The activities of soluble calcium-dependent and calcium-independent PKC were higher in HO than in control rats (both roughly 30%); membrane-associated PKCs were not modified. The data indicate that HO induces an increased responsiveness of M1AChRs and mGluRs and a rise in the soluble PKC activity that could be available and ready for translocation. | lld:pubmed |
| pubmed-article:8726960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8726960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8726960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8726960 | pubmed:month | May | lld:pubmed |
| pubmed-article:8726960 | pubmed:issn | 0364-3190 | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:BattainiFF | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:PascaleAA | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:LorenziniPP | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:SalvatiSS | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:PintorAA | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:FortunaSS | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:AvelliniMM | lld:pubmed |
| pubmed-article:8726960 | pubmed:author | pubmed-author:Malvezzi... | lld:pubmed |
| pubmed-article:8726960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8726960 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:8726960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8726960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8726960 | pubmed:pagination | 541-5 | lld:pubmed |
| pubmed-article:8726960 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:meshHeading | pubmed-meshheading:8726960-... | lld:pubmed |
| pubmed-article:8726960 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8726960 | pubmed:articleTitle | Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats. | lld:pubmed |
| pubmed-article:8726960 | pubmed:affiliation | Istituto Superiore di Sanità, Department of Pharmacology, Roma, Italy. | lld:pubmed |
| pubmed-article:8726960 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8726960 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
