| pubmed-article:8723762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8723762 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8723762 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8723762 | pubmed:dateCreated | 1996-10-24 | lld:pubmed |
| pubmed-article:8723762 | pubmed:abstractText | Microglia rapidly respond to lipoplysaccharide (LPS) by transformation from resting to active states and secretion of several neuro- and immuno-regulators including tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6). With longer LPS treatment, microglia are converted to reactive or phagocytic states with characteristics similar to macrophages in inflammation and injury processes. We have investigated LPS-mediated changes in two myristoylated substrates of protein kinase C (PKC): MARCKS (myristoylated alaninerich C kinase substrate) and MRP (MARCKS-related protein). Within 6 hours of addition, LPS induced a twofold increase in [3H]myristoylated and immunoreactive MARCKS protein and a sevenfold increase in MRP. The differential effect of LPS on expression of MRP vs. MARCKS was even more dramatic at the level of transcription: S1 nuclease protection assays revealed a 40-fold increase in MRP mRNA levels (maximum at 4-6 hours), whereas a threefold increase was observed for MARCKS. TNF alpha and colony-stimulating factor 1 (CSF-1), two cytokines which are induced by LPS, did not reproduce the observed effect of LPS on MARCKS and MRP gene transcription. CSF-1 also induced differential transcription of MRP, but of lower magnitude (threefold) and more sustained than by LPS. Accordingly, these two substrates for PKC are differentially up-regulated by LPS, apparently independent of TNF alpha or CSF-1. | lld:pubmed |
| pubmed-article:8723762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8723762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8723762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8723762 | pubmed:month | May | lld:pubmed |
| pubmed-article:8723762 | pubmed:issn | 0360-4012 | lld:pubmed |
| pubmed-article:8723762 | pubmed:author | pubmed-author:FedoroffSS | lld:pubmed |
| pubmed-article:8723762 | pubmed:author | pubmed-author:ByersD MDM | lld:pubmed |
| pubmed-article:8723762 | pubmed:author | pubmed-author:CookH WHW | lld:pubmed |
| pubmed-article:8723762 | pubmed:author | pubmed-author:MorashS CSC | lld:pubmed |
| pubmed-article:8723762 | pubmed:author | pubmed-author:RoséS DSD | lld:pubmed |
| pubmed-article:8723762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8723762 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8723762 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:8723762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8723762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8723762 | pubmed:pagination | 235-42 | lld:pubmed |
| pubmed-article:8723762 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
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| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
| pubmed-article:8723762 | pubmed:meshHeading | pubmed-meshheading:8723762-... | lld:pubmed |
| pubmed-article:8723762 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8723762 | pubmed:articleTitle | Lipopolysaccharide stimulates differential expression of myristoylated protein kinase C substrates in murine microglia. | lld:pubmed |
| pubmed-article:8723762 | pubmed:affiliation | Atlantic Research Centre, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. | lld:pubmed |
| pubmed-article:8723762 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8723762 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
