| pubmed-article:8709273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C1623048 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C1707391 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C1709474 | lld:lifeskim |
| pubmed-article:8709273 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8709273 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8709273 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8709273 | pubmed:abstractText | Vesicular stomatitis virus (VSV) populations were repeatedly passaged in L-929 cells treated with alpha interferon (IFN-alpha) at levels of 25 U/ml. This IFN-alpha concentration induced a 99.9% inhibition of viral yield in standard infections. Analysis of viral fitness (overall replicative ability measured in direct competition with a reference wild-type VSV) after 21 passages in IFN-treated cells showed only a limited increase or no increase in fitness, compared with the greater increase upon parallel passage in cells not treated with IFN-alpha. However, this limited increase in fitness was more pronounced when competition assays were carried out with IFN-alpha-treated cells, suggesting the selection of VSV populations with a low level of resistance to IFN-alpha. Thus, despite the extensively documented capacity of VSV to adapt to changing environments, the antiviral state induced by IFN-alpha imposes adaptive constraints on VSV which are not readily overcome. | lld:pubmed |
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| pubmed-article:8709273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8709273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709273 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8709273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8709273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8709273 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8709273 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:KohlHH | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:HollandJ JJJ | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:DomingoEE | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:MoyaAA | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:ElenaS FSF | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:NovellaI SIS | lld:pubmed |
| pubmed-article:8709273 | pubmed:author | pubmed-author:CilnisMM | lld:pubmed |
| pubmed-article:8709273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8709273 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8709273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8709273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8709273 | pubmed:pagination | 6414-7 | lld:pubmed |
| pubmed-article:8709273 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:meshHeading | pubmed-meshheading:8709273-... | lld:pubmed |
| pubmed-article:8709273 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8709273 | pubmed:articleTitle | Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance. | lld:pubmed |
| pubmed-article:8709273 | pubmed:affiliation | Department of Biology, University of California, San Diego, La Jolla, 92093-0116, USA. | lld:pubmed |
| pubmed-article:8709273 | pubmed:publicationType | Journal Article | lld:pubmed |
