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pubmed-article:8708716pubmed:abstractTextMethotrexate (MTX) has been described to modulate the activity of fluorouracil (5-FU) in patients with metastatic colorectal cancer. The European Organization for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Cooperative Group (GITCCG) conducted a phase III trial to investigate the efficacy and tolarability of the addition of low-dose MTX (40 mg/m2) to high-dose infusional 5-FU (60 mg/kg over 48 hours) given weekly for 4 weeks and thereafter every 2 (for 4 weeks) and 3 weeks.lld:pubmed
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pubmed-article:8708716pubmed:articleTitleModulation of high-dose infusional fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer: final results of a randomized European Organization for Research and Treatment of Cancer Study.lld:pubmed
pubmed-article:8708716pubmed:affiliationEuropean Organization for Research and Treatment of Cancer, Gastrointestinal Tract Cancer Cooperative Group, Brussels, Belgium.lld:pubmed
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