| pubmed-article:8706033 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8706033 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8706033 | lifeskim:mentions | umls-concept:C0037286 | lld:lifeskim |
| pubmed-article:8706033 | lifeskim:mentions | umls-concept:C0221715 | lld:lifeskim |
| pubmed-article:8706033 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:8706033 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:8706033 | pubmed:dateCreated | 1996-9-10 | lld:pubmed |
| pubmed-article:8706033 | pubmed:abstractText | Hereditary nonpolyposis colorectal cancer is associated with defects in DNA mismatch repair. Here, we characterize tumor susceptibility of the recently described Msh2-deficient mouse model. Within the first year of observation, all homozygous mice succumbed to disease, with lymphomas observed in at least 80% of the cases. The majority (70%) of animals 6 months or older developed intestinal neoplasms associated with APC inactivation. Microsatellite instability was more common in carcinomas than in adenomas, but uncommon in normal tissues. Some animals (7%) developed a variety of skin neoplasms analogous to the Muir-Torre syndrome. Msh2-/- mice implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans. | lld:pubmed |
| pubmed-article:8706033 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8706033 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8706033 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8706033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8706033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8706033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8706033 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8706033 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8706033 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:ChengHH | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:IDAMM | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:GallingerSS | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:LAXS RSR | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:BapatBB | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:BjerknesMM | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:RedstonMM | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:ReitmairA HAH | lld:pubmed |
| pubmed-article:8706033 | pubmed:author | pubmed-author:ChuangT CTC | lld:pubmed |
| pubmed-article:8706033 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8706033 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8706033 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8706033 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8706033 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8706033 | pubmed:pagination | 3842-9 | lld:pubmed |
| pubmed-article:8706033 | pubmed:dateRevised | 2009-7-24 | lld:pubmed |
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| pubmed-article:8706033 | pubmed:meshHeading | pubmed-meshheading:8706033-... | lld:pubmed |
| pubmed-article:8706033 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8706033 | pubmed:articleTitle | Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. | lld:pubmed |
| pubmed-article:8706033 | pubmed:affiliation | Department of Medical Biophysics, Ontario Cancer Institute/Amgen Institute, University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:8706033 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8706033 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17685 | entrezgene:pubmed | pubmed-article:8706033 | lld:entrezgene |
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