| pubmed-article:8703031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C1442761 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:8703031 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:8703031 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:8703031 | pubmed:dateCreated | 1996-10-10 | lld:pubmed |
| pubmed-article:8703031 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8703031 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8703031 | pubmed:abstractText | We isolated and characterized the gene for the human thyrotropin-releasing hormone receptor. The gene spanned more than 30 kilobases and contained three exons and two introns. Intron 1 exists in the 5'-untranslated region, and intron 2 is more than 25 kilobases in length which interrupts the coding region before the beginning of the putative sixth transmembrane domain. Exon 3 encodes the rest of the coding region and the entire 3'-untranslated region. The 3'-flanking region contains four potential polyadenylation signals, and 3'-rapid amplification of cDNA ends studies showed that only a signal at 2076 base pairs downstream of the stop codon was functional in the anterior pituitary. Primer extension and anchor-polymerase chain reaction studies indicated a transcriptional start site at 344 base pairs upstream of the translational start site. The promoter region does not contain either a TATA box or a CAAT box in the appropriate location. Transient transfection study revealed significant activity of the promoter in GH4C1 cells, and the region between -338 and -933 bp from the transcriptional start site worked as a negative regulator. Knowledge of the genomic organization and the promoter region of thyrotropin-releasing hormone (TRH) receptor gene will allow further studies of possible disorders of the TRH receptor, as well as facilitate elucidation of transcriptional control of the human TRH receptor gene. | lld:pubmed |
| pubmed-article:8703031 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8703031 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8703031 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8703031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8703031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8703031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8703031 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8703031 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:KatoYY | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:IwasakiTT | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:YamadaMM | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:HashimotoKK | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:MoriMM | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:ReaLL | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:SatohTT | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:KonakaSS | lld:pubmed |
| pubmed-article:8703031 | pubmed:author | pubmed-author:KohgaHH | lld:pubmed |
| pubmed-article:8703031 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8703031 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:8703031 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8703031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8703031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8703031 | pubmed:pagination | 22183-8 | lld:pubmed |
| pubmed-article:8703031 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:meshHeading | pubmed-meshheading:8703031-... | lld:pubmed |
| pubmed-article:8703031 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8703031 | pubmed:articleTitle | Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. | lld:pubmed |
| pubmed-article:8703031 | pubmed:affiliation | First Department of Internal Medicine, Gunma University School of Medicine, Maebashi 371 Japan. | lld:pubmed |
| pubmed-article:8703031 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:7201 | entrezgene:pubmed | pubmed-article:8703031 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8703031 | lld:pubmed |
