Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8699136rdf:typepubmed:Citationlld:pubmed
pubmed-article:8699136lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0439849lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0036536lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0036537lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0022131lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0004561lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0017687lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0021641lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0006674lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0008318lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0441889lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0011155lld:lifeskim
pubmed-article:8699136lifeskim:mentionsumls-concept:C0108048lld:lifeskim
pubmed-article:8699136pubmed:issue2lld:pubmed
pubmed-article:8699136pubmed:dateCreated1996-9-5lld:pubmed
pubmed-article:8699136pubmed:abstractTextThe pancreatic B cell is equipped with specific receptors for 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and contains vitamin D-dependent calcium binding proteins (calbindin-D). Insulin secretion is impaired by vitamin D deficiency and is restored by 1,25-(OH)2D3 (concomitantly with an improved calcium handling within B cells) but the effect of 1,25-(OH)2D3 on the pancreatic B cell via calbindin-D is unclear. Therefore we examined the relationship between calbindin-D28K or calbindin-D9K and the activity of the endocrine pancreas in normal (N), four week vitamin D-deficient (-D) and one week 1,25-(OH)2D3-replete (+D) rats. Calbindin-D9K was not found in the pancreas, neither in the islets nor in the exocrine part, of any of the groups of rats (N, -D, or+D). Surprisingly, total islet calbindin-D28K content was increased by vitamin D deficiency and partly restored by 1,25-(OH)2D3. Calbindin-D28K immunostaining was observed only on A and B cells in the endocrine part of the pancreas, the greatest staining being found in A cells. This difference in staining density was increased by vitamin D deficiency and decreased by 1,25-(OH)2D3 treatment. In vitro, 1,25-(OH)2D3 also produced a negative influence on calbindin-D28K staining in A cells, as demonstrated using pieces of pancreas incubated with the steroid for 2 h. No significant influence on labeling intensity of B cell calbindin-D28K could be shown. Plasma insulin and islet insulin release in response to 10 mM arginine stimulation were decreased in -D rats and enhanced in +D rats towards N values. In contrast, plasma glucagon and the amount of glucagon secretion, stimulated in vitro by 10 mM arginine or by low (1.7 mM) glucose concentration, was increased in -D rats and attenuated by 1,25-(OH)2D3. Thus there appears to be no relationship between the steady state level of B cell calbindin-D28K and the regulation of insulin secretion by 1,25-(OH)2D3 in vitamin D-deficient rats. However there is a correlation between A cell calbindin-D28K and glucagon secretion, which are both negatively regulated by 1,25-(OH)2D3. The predominance of calbindin-D28K in A cells raises the question as to how A and B cells interact and the role of calbindin-D28K in calcium handling.lld:pubmed
pubmed-article:8699136pubmed:languageenglld:pubmed
pubmed-article:8699136pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:citationSubsetIMlld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8699136pubmed:statusMEDLINElld:pubmed
pubmed-article:8699136pubmed:monthFeblld:pubmed
pubmed-article:8699136pubmed:issn0022-0795lld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:ThomassetMMlld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:BillaudelBBlld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:TramuGGlld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:SutterB CBClld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:BourlonP MPMlld:pubmed
pubmed-article:8699136pubmed:authorpubmed-author:Faure-Dussert...lld:pubmed
pubmed-article:8699136pubmed:issnTypePrintlld:pubmed
pubmed-article:8699136pubmed:volume148lld:pubmed
pubmed-article:8699136pubmed:ownerNLMlld:pubmed
pubmed-article:8699136pubmed:authorsCompleteYlld:pubmed
pubmed-article:8699136pubmed:pagination223-32lld:pubmed
pubmed-article:8699136pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:meshHeadingpubmed-meshheading:8699136-...lld:pubmed
pubmed-article:8699136pubmed:year1996lld:pubmed
pubmed-article:8699136pubmed:articleTitleRelationship between calbindin-D28K levels in the A and B cells of the rat endocrine pancreas and the secretion of insulin and glucagon: influence of vitamin D3 deficiency and 1,25-dihydroxyvitamin D3.lld:pubmed
pubmed-article:8699136pubmed:affiliationLaboratoire Endocrinologie, Université Bordeaux I, Talence, France.lld:pubmed
pubmed-article:8699136pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8699136pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8699136pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:8699136pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8699136lld:pubmed