| pubmed-article:8693001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0007226 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:8693001 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:8693001 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:8693001 | pubmed:dateCreated | 1996-8-29 | lld:pubmed |
| pubmed-article:8693001 | pubmed:abstractText | At least three distinct beta-adrenergic receptor (beta-AR) subtypes exist in mammals. These receptors modulate a wide variety of processes, from development and behavior, to cardiac function, metabolism, and smooth muscle tone. To understand the roles that individual beta-AR subtypes play in these processes, we have used the technique of gene targeting to create homozygous beta 1-AR null mutants (beta 1-AR -/-) in mice. The majority of beta 1-AR -/- mice die prenatally, and the penetrance of lethality shows strain dependence. Beta l-AR -/- mice that do survive to adulthood appear normal, but lack the chronotropic and inotropic responses seen in wild-type mice when beta-AR agonists such as isoproterenol are administered. Moreover, this lack of responsiveness is accompanied by markedly reduced stimulation of adenylate cyclase in cardiac membranes from beta 1-AR -/- mice. These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes. | lld:pubmed |
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| pubmed-article:8693001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8693001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8693001 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8693001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8693001 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8693001 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:BernsteinDD | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:BarshG SGS | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:StevensM EME | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:JasperJ RJR | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:KobilkaB KBK | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:RohrerD KDK | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:RegulaD PDPJr | lld:pubmed |
| pubmed-article:8693001 | pubmed:author | pubmed-author:DesaiK HKH | lld:pubmed |
| pubmed-article:8693001 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8693001 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:8693001 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8693001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8693001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8693001 | pubmed:pagination | 7375-80 | lld:pubmed |
| pubmed-article:8693001 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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