| pubmed-article:8691138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8691138 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8691138 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8691138 | pubmed:dateCreated | 1996-8-29 | lld:pubmed |
| pubmed-article:8691138 | pubmed:abstractText | Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD. Our aim was to identify which cell type(s) can mediate colitis in IL-10-/- mice. We detected an influx of immunoglobulin-positive cells into the colon and the presence of colon-reactive antibodies in the serum of IL-10-/- mice. To assess a pathogenic role for B cells, we generated a B cell-deficient (B-/-) strain of IL-10-/- mice. B-/-IL-10-/- mice acquired a severe colitis analogous to that IL-10-/- mice, implying that B cells were not the primary mediator of IBD in this model. A series of cell transfer experiments was performed to assess a pathogenic role for T cells. When IL-10-/- T cell-enriched lamina propria lymphocytes (LPL) or intraepithelial lymphocytes (IEL) were transferred into immunodeficient recombinase-activating gene (RAG)-2-/- recipients, a mild to severe colitis developed, depending on the cell number transferred. Lymphocytes recovered from the colon of transplanted RAG-2-/- mice with colitis were predominantly alpha beta TCR+CD4+, including a large proportion of CD4+CD8 alpha + cells. These cells were also CD45RB-/low and CD44+, indicative of an activated/memory population. Individual populations of CD4+CD8 alpha-, CD4+CD8 alpha + and CD4-CD8 alpha + T cells were then isolated from the lamina propria compartment of IL-10-/- mice and transferred into RAG-2-/- recipients. Only IL-10-/- CD4-expressing LPL, including both the CD4+CD8 alpha- and CD4+CD8 alpha + populations, induced colitis in recipient mice. Interferon-gamma, but little to no IL-4, was produced by CD4+CD8 alpha- and CD4+CD8 alpha + LPL recovered from the inflamed colons of RAG-2-/- recipients implicating alpha T helper cell 1 (TH1)-mediated response. We thus conclude that colitis in IL-10-/- mice is predominantly mediated by TH1-type alpha beta TCR+ T cells expressing CD4 alone, or in combination with the CD8 alpha molecule. | lld:pubmed |
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| pubmed-article:8691138 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8691138 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8691138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8691138 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8691138 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:MüllerWW | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:RennickD MDM | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:KühnRR | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:BirdH GHG | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:Thompson-Snip... | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:DavidsonN JNJ | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:FortM MMM | lld:pubmed |
| pubmed-article:8691138 | pubmed:author | pubmed-author:LeachM WMW | lld:pubmed |
| pubmed-article:8691138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8691138 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8691138 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8691138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8691138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8691138 | pubmed:pagination | 241-51 | lld:pubmed |
| pubmed-article:8691138 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8691138 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8691138 | pubmed:articleTitle | T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. | lld:pubmed |
| pubmed-article:8691138 | pubmed:affiliation | DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, California 94304, USA. | lld:pubmed |
| pubmed-article:8691138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8691138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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