| pubmed-article:8688553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0032246 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0032578 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0385333 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C1332721 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8688553 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:8688553 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8688553 | pubmed:dateCreated | 1996-8-29 | lld:pubmed |
| pubmed-article:8688553 | pubmed:abstractText | The pathways that regulate the S-phase events associated with the control of DNA replication are poorly understood. The bone marrow megakaryocytes are unique in that they leave the diploid (2C) state to differentiate, synthesizing 4 to 64 times the normal DNA content within a single nucleus, a process known as endomitosis. Human erythroleukemia (HEL) cells model this process, becoming polyploid during phorbol diester-induced megakaryocyte differentiation. The mitotic arrest occurring in these polyploid cells involves novel alterations in the cdk1/cyclin B1 complex: a marked reduction in cdk1 protein levels, and an elevated and sustained expression of cyclin B1. Endomitotic cells thus lack cdk1/cyclin B1-associated H1-histone kinase activity. Constitutive over-expression of cdk1 in endomitotic cells failed to re-initiate normal mitotic events even though cdk1 was present in a 10-fold excess. This was due to an inability of cyclin-B1 to physically associate with cdk1. Nonetheless, endomitotic cyclin B1 possesses immunoprecipitable H1-histone kinase activity, and specifically translocates to the nucleus. We conclude that mitosis is abrogated during endomitosis due to the absence of cdk1 and the failure to form M-phase promoting factor, resulting in a disassociation of mitosis from the completion of S-phase. Further studies on cyclin and its interacting proteins should be informative in understanding endomitosis and cell cycle control. | lld:pubmed |
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| pubmed-article:8688553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8688553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8688553 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8688553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8688553 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8688553 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:CaldwellJJ | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:DattaN SNS | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:WilliamsJ LJL | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:LongM WMW | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:CurryA MAM | lld:pubmed |
| pubmed-article:8688553 | pubmed:author | pubmed-author:AshcraftE KEK | lld:pubmed |
| pubmed-article:8688553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8688553 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8688553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8688553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8688553 | pubmed:pagination | 209-23 | lld:pubmed |
| pubmed-article:8688553 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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