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pubmed-article:8686788pubmed:abstractTextErythrocytes infected with malaria parasites often contain membranous vesicles that are presumed to facilitate macromolecule traffic between the parasite and erythrocyte membranes. One such vesicle network, called Maurer's clefts, is expressed in Plasmodium falciparum-infected erythrocytes and contains a 50-kD polypeptide. Using a monoclonal antibody reactive with this polypeptide, we show that hepatic stages of P. falciparum express an epitope common to this blood-stage antigen. In addition, this epitope is cross-reactive with antigens expressed by primate leukocytes and platelets. Such epitopes may induce autoantibodies commonly seen in patients with malaria.lld:pubmed
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pubmed-article:8686788pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8686788pubmed:articleTitleCross-reactive epitope among proteins in Plasmodium falciparum Maurer's clefts and primate leukocytes and platelets.lld:pubmed
pubmed-article:8686788pubmed:affiliationDepartment of Immunology, Walter Reed Army Institute of Research, Washington, District of Columbia, USA.lld:pubmed
pubmed-article:8686788pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8686788pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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