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pubmed-article:8686168pubmed:abstractTextThe immunomodulatory role of Mycobacterium phlei against intracellular blood protozoan Babesia bigemina was demonstrated following experimental immunisation and challenge in bovine calves. A lysate of erythrocytes infected (6 x 10(9)) with B. bigemina was used as a source of dead antigen either with Freund's complete adjuvant (FCA) or with a trypsinised culture of M. phlei as a non-specific immunomodulation (NSI) agent with appropriate controls. Following virulent challenge with B. bigemina infected erythrocytes (1 x 10(7)), the NSI printed calves showed 100% protection, while the dead antigen alone with FCA afforded 75% protection. The protective status of the immunising regimes was studied by clinicopathological parameters and assessment of humoral and cell-mediated immune responses. The role of babesial dead antigen and the effects of M. phlei on the development of immunity to B. bigemina is discussed.lld:pubmed
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pubmed-article:8686168pubmed:authorpubmed-author:DasS KSKlld:pubmed
pubmed-article:8686168pubmed:authorpubmed-author:MishraA KAKlld:pubmed
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pubmed-article:8686168pubmed:authorpubmed-author:RaoJ RJRlld:pubmed
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pubmed-article:8686168pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:8686168pubmed:year1996lld:pubmed
pubmed-article:8686168pubmed:articleTitleEffect of Mycobacterium phlei on the development of immunity to Babesia bigemina.lld:pubmed
pubmed-article:8686168pubmed:affiliationDivision of Parasitology, Indian Veterinary Research Institute, Izatnagar, India.lld:pubmed
pubmed-article:8686168pubmed:publicationTypeJournal Articlelld:pubmed
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