| pubmed-article:8682789 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0004595 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0014406 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C0815047 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C1709450 | lld:lifeskim |
| pubmed-article:8682789 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:8682789 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:8682789 | pubmed:dateCreated | 1996-8-20 | lld:pubmed |
| pubmed-article:8682789 | pubmed:abstractText | In Bacillus subtilis, activity of the general stress transcription factor sigma B is controlled posttranslationally by a regulatory network that transmits signals of environmental and metabolic stress. These signals include heat, ethanol, or osmotic challenge, or a sharp decrease in cellular energy levels, and all ultimately control sigma B activity by influencing the binding decision of the RsbW anti-sigma factor. In the absence of stress, RsbW binds to sigma B and prevents its association with RNA polymerase core enzyme. However, following stress, RsbW binds instead to the RsbV anti-anti-sigma factor, thereby releasing sigma B to direct transcription of its target genes. These two principal regulators of sigmaB activity are encoded in the eight-gene sigB operon, which has the gene order rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sig B-rsbX (where rsb stands for regulator of sigma B). Notably, the predicted rsbS product has significant amino acid identity to the RsbV anti-anti-sigma factor and the predicted rsbT product resembles the RsbW anti-sigma factor. To determine the roles of rsbS and rsbT, null or missense mutations were constructed in the chromosomal copies or each and tested for their effects on expression of a sigma B-dependent reporter fusion. On the basis of this genetic analysis, our principal conclusions are that (i) the rsbS product is a negative regulator of or" activity, (ii) the rsbT product is a positive regulator, (iii) RsbS requires RsbT for function, and (iv) the RsbS-RsbT and RsbV-RsbW pairs act hierarchically by a common mechanism in which key protein-protein interactions are controlled by phosphorylation events. | lld:pubmed |
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| pubmed-article:8682789 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8682789 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8682789 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8682789 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8682789 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8682789 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:8682789 | pubmed:author | pubmed-author:PriceC WCW | lld:pubmed |
| pubmed-article:8682789 | pubmed:author | pubmed-author:BrodyM SMS | lld:pubmed |
| pubmed-article:8682789 | pubmed:author | pubmed-author:AkbarSS | lld:pubmed |
| pubmed-article:8682789 | pubmed:author | pubmed-author:YangXX | lld:pubmed |
| pubmed-article:8682789 | pubmed:author | pubmed-author:KangC MCM | lld:pubmed |
| pubmed-article:8682789 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8682789 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:8682789 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8682789 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8682789 | pubmed:pagination | 3846-53 | lld:pubmed |
| pubmed-article:8682789 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8682789 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8682789 | pubmed:articleTitle | Homologous pairs of regulatory proteins control activity of Bacillus subtilis transcription factor sigma(b) in response to environmental stress. | lld:pubmed |
| pubmed-article:8682789 | pubmed:affiliation | Department of Food Science and Technology, University of California, Davis 95616, USA. | lld:pubmed |
| pubmed-article:8682789 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8682789 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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