| pubmed-article:8680480 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8680480 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8680480 | lifeskim:mentions | umls-concept:C1414069 | lld:lifeskim |
| pubmed-article:8680480 | lifeskim:mentions | umls-concept:C1159884 | lld:lifeskim |
| pubmed-article:8680480 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8680480 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8680480 | pubmed:dateCreated | 1996-8-16 | lld:pubmed |
| pubmed-article:8680480 | pubmed:abstractText | Differentiation of preadipocytes to mature adipocytes is accompanied by marked increases in enzymes of lipid metabolism and cytoskeletal remodelling of fibroblastic preadipocytes to rounded lipid-filled mature adipocytes. Studies to date indicate this process is under the control of specific transcription factors, cell-cell and cell-environment interactions. Preadipocyte factor-1 (pref-1), a member of the EGF-like protein family, was identified during the differential screening of cDNAs expressed in differentiating preadipocytes. Multiple forms of the protein are present in 3T3-L1 preadipocytes with heterogeneity attributable both to alternate splicing and various post-translational modifications. Pref-1 is unique in that its expression is completely abolished during the maturation of preadipocytes to adipocytes. Moreover, blocking down-regulation via constitutive expression of pref-1 in preadipocytes inhibits their differentiation. The expression pattern of pref-1 in embryonic tissues and its presence in tumors indicate that in addition to its function in adipocyte differentiation, pref-1 may have a broader role in differentiation and development. | lld:pubmed |
| pubmed-article:8680480 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8680480 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8680480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8680480 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8680480 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8680480 | pubmed:issn | 0307-0565 | lld:pubmed |
| pubmed-article:8680480 | pubmed:author | pubmed-author:SulH SHS | lld:pubmed |
| pubmed-article:8680480 | pubmed:author | pubmed-author:SmasC MCM | lld:pubmed |
| pubmed-article:8680480 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8680480 | pubmed:volume | 20 Suppl 3 | lld:pubmed |
| pubmed-article:8680480 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8680480 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8680480 | pubmed:pagination | S65-72 | lld:pubmed |
| pubmed-article:8680480 | pubmed:dateRevised | 2006-11-20 | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:meshHeading | pubmed-meshheading:8680480-... | lld:pubmed |
| pubmed-article:8680480 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8680480 | pubmed:articleTitle | Characterization of Pref-1 and its inhibitory role in adipocyte differentiation. | lld:pubmed |
| pubmed-article:8680480 | pubmed:affiliation | Department of Nutritional Sciences, University of California, Berkeley 94720, USA. | lld:pubmed |
| pubmed-article:8680480 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8680480 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8680480 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:8680480 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8680480 | lld:pubmed |
