Linked Life Data

8674892

Source:http://linkedlifedata.com/resource/pubmed/id/8674892

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8674892rdf:typepubmed:Citationlld:pubmed
pubmed-article:8674892lifeskim:mentionsumls-concept:C0028754lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C2700303lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0026820lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0003483lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0021655lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0542341lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0205161lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0205217lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C1832073lld:lifeskim
pubmed-article:8674892lifeskim:mentionsumls-concept:C0596235lld:lifeskim
pubmed-article:8674892pubmed:dateCreated1996-8-15lld:pubmed
pubmed-article:8674892pubmed:abstractTextTo investigate the role of hyperinsulinemia/insulin resistance in vasomotor tone regulation, we studied the effects of vasoactive substances on tension and intracellular free calcium concentration ([Ca2+]i) of aortic smooth muscle derived from rats that were made hyperinsulinemic by insulin infusion and from Zucker obese rats with insulin resistance. The tension and [Ca2+]i of fura 2-loaded aortic strip preparations without endothelium were simultaneously measured by using a fluorimeter. Ten male Wistar rats received a continuous subcutaneous infusion of insulin (18 nmol x kg(-1) x day(-1)) for 2 weeks with osmotic minipumps (INS group). A control group of 10 rats received vehicle. The plasma immunoreactive insulin concentration in the INS group increased to 930 +/- 54 pmol/l. The increase in [Ca2+]i and tension by KCl and phenylephrine (PE) were lower in the INS group without alteration of the [Ca2+]i-tension relationship. The responses to serotonin (5-HT) in the INS group were similar to those in the control group. In contrast, responses to KCl, PE and 5-HT were markedly enhanced in Zucker obese rats compared with those in Zucker lean rats. The pretreatment of aortic preparations from lean rats with Bay K8644 significantly enhanced the responses to KCl to the level observed in the preparations from obese rats; however, Bay K 8644 failed to affect the responses to KCl in obese rats. These results suggest that enhanced vascular contractile responses to vasoactive substances, possibly due to altered function of the voltage-dependent Ca2+ channel in vascular smooth muscle, may play an important role in the pathogenesis of hypertension in the insulin resistance syndrome.lld:pubmed
pubmed-article:8674892pubmed:languageenglld:pubmed
pubmed-article:8674892pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:citationSubsetAIMlld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8674892pubmed:statusMEDLINElld:pubmed
pubmed-article:8674892pubmed:monthJullld:pubmed
pubmed-article:8674892pubmed:issn0012-1797lld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:OrimoHHlld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:KimSSlld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:ToazEElld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:OrlovV AVAlld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:KozakiKKlld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:AkishitaMMlld:pubmed
pubmed-article:8674892pubmed:authorpubmed-author:RAOK MKMlld:pubmed
pubmed-article:8674892pubmed:issnTypePrintlld:pubmed
pubmed-article:8674892pubmed:volume45 Suppl 3lld:pubmed
pubmed-article:8674892pubmed:ownerNLMlld:pubmed
pubmed-article:8674892pubmed:authorsCompleteYlld:pubmed
pubmed-article:8674892pubmed:paginationS55-8lld:pubmed
pubmed-article:8674892pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:meshHeadingpubmed-meshheading:8674892-...lld:pubmed
pubmed-article:8674892pubmed:year1996lld:pubmed
pubmed-article:8674892pubmed:articleTitleAugmented contractile function and abnormal Ca2+ handling in the aorta of Zucker obese rats with insulin resistance.lld:pubmed
pubmed-article:8674892pubmed:affiliationDepartment of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.lld:pubmed
pubmed-article:8674892pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8674892pubmed:publicationTypeIn Vitrolld:pubmed