| pubmed-article:8674276 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C1609982 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C1527144 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:8674276 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8674276 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8674276 | pubmed:dateCreated | 1996-8-15 | lld:pubmed |
| pubmed-article:8674276 | pubmed:abstractText | Despite considerable advancement in anticancer therapy, minimal residual disease (MRD) is still a major problem in the clinical management of cancer, including lymphoma. In this report, we have studied the antitumor effects of interleukin-12 (IL-12) against an aggressive liver metastatic murine RAW117-H10 lymphoma. Our results using three different doses of IL-12 (0.175, 0.35 and 0.7 micrograms/mouse) showed that a 0.35 micrograms dose is the most efficacious against lymphoma grown in intact mice. Furthermore, we have evaluated the therapeutic effects of IL-12 against residual lymphoma in a transplantation setting. BALB/c mice were treated with high-dose therapy (HDT) and transplanted with syngeneic bone marrow cells added with a known number of RAW117-H10 lymphoma cells to mimic the clinical situation of MRD. The mice were then treated with IL-12 (0.25 micrograms/mouse/day) alone or IL-12 plus activated cytotoxic effector cells. Our results showed that IL-12 had a significant (P < 0.05) antitumor therapeutic effect against liver metastatic lymphoma grown in intact mice as well as in lymphoma-bearing mice treated with HDT followed by stem cell transplantation as determined by survival period. The therapeutic effect of IL-12 was also demonstrated by a very significant decrease (P < 0.05) in the tumor burden in livers from the IL-12-treated mice. Mice that were treated with IL-12 following HDT and hematopoietic stem cell transplantation had a significant decrease in circulating white blood cells (P < 0.05), a significant increase in spleen weight and cellularity (P < 0.05), and hematopoietic progenitor cells (P < 0.05), a significant increase in the number of splenocytes expressing IL-2 alpha-chain receptor (P < 0.05), and an increase in the frequency of natural killer cells in their spleens. These studies suggest that cytokines such as IL-12 may have the potential to mediate antitumor effects against residual lymphoma without compromising lymphohematopoietic recovery. | lld:pubmed |
| pubmed-article:8674276 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8674276 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674276 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8674276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8674276 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8674276 | pubmed:month | May | lld:pubmed |
| pubmed-article:8674276 | pubmed:issn | 0262-0898 | lld:pubmed |
| pubmed-article:8674276 | pubmed:author | pubmed-author:BrundaM JMJ | lld:pubmed |
| pubmed-article:8674276 | pubmed:author | pubmed-author:KessingerAA | lld:pubmed |
| pubmed-article:8674276 | pubmed:author | pubmed-author:JoshiS SSS | lld:pubmed |
| pubmed-article:8674276 | pubmed:author | pubmed-author:StinsonW WWW | lld:pubmed |
| pubmed-article:8674276 | pubmed:author | pubmed-author:VerbikD JDJ | lld:pubmed |
| pubmed-article:8674276 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8674276 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8674276 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8674276 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8674276 | pubmed:pagination | 219-29 | lld:pubmed |
| pubmed-article:8674276 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
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| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:meshHeading | pubmed-meshheading:8674276-... | lld:pubmed |
| pubmed-article:8674276 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8674276 | pubmed:articleTitle | In vivo therapeutic effects of interleukin-12 against highly metastatic residual lymphoma. | lld:pubmed |
| pubmed-article:8674276 | pubmed:affiliation | Department of Cell Biology, University of Nebraska Medical Center, Omaha, USA. | lld:pubmed |
| pubmed-article:8674276 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8674276 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
