| pubmed-article:8670888 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8670888 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8670888 | lifeskim:mentions | umls-concept:C0208355 | lld:lifeskim |
| pubmed-article:8670888 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:8670888 | lifeskim:mentions | umls-concept:C2610925 | lld:lifeskim |
| pubmed-article:8670888 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:8670888 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:8670888 | pubmed:dateCreated | 1996-10-10 | lld:pubmed |
| pubmed-article:8670888 | pubmed:abstractText | Cell death in many different organisms requires the activation of proteolytic cascades involving cytosolic proteases. Here we describe a novel requirement in thymocyte cell death for the 20S proteasome, a highly conserved multicatalytic protease found in all eukaryotes. Specific inhibitors of proteasome function blocked cell death induced by ionizing radiation, glucocorticoids or phorbol ester. In addition to inhibiting apoptosis, these signals prevented the cleavage of poly(ADP-ribose) polymerase that accompanies many cell deaths. Since overall rates of protein degradation were not altered significantly during cell death in thymocytes, these results suggest that the proteasome may either degrade regulatory protein(s) that normally inhibit the apoptotic pathway or may proteolytically activate protein(s) than promote cell death. | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8670888 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670888 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8670888 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8670888 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:8670888 | pubmed:author | pubmed-author:PoirierG GGG | lld:pubmed |
| pubmed-article:8670888 | pubmed:author | pubmed-author:GoldbergA LAL | lld:pubmed |
| pubmed-article:8670888 | pubmed:author | pubmed-author:OsborneB ABA | lld:pubmed |
| pubmed-article:8670888 | pubmed:author | pubmed-author:SchwartzL MLM | lld:pubmed |
| pubmed-article:8670888 | pubmed:author | pubmed-author:GrimmL MLM | lld:pubmed |
| pubmed-article:8670888 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8670888 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8670888 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:8670888 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8670888 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8670888 | pubmed:pagination | 3835-44 | lld:pubmed |
| pubmed-article:8670888 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
| pubmed-article:8670888 | pubmed:meshHeading | pubmed-meshheading:8670888-... | lld:pubmed |
