| pubmed-article:8670117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C1166717 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0041217 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:8670117 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:8670117 | pubmed:dateCreated | 1996-8-5 | lld:pubmed |
| pubmed-article:8670117 | pubmed:abstractText | Acidocalcisomes are acidic vacuoles present in trypanosomatids that contain a considerable fraction of intracellular Ca2+ [Vercesi, Moreno and Docampo (1994) Biochem. J. 304, 227-233; Scott, Moreno and Docampo (1995) Biochem. J. 310, 789-794; Docampo, Scott, Vercesi and Moreno (1995) Biochem. J. 310, 1005-1012]. The data presented here indicate that Na+ stimulates Ca2+ release from the acidocalcisomes of digitonin-permeabilized Trypanosoma brucei procyclic trypomastigotes in a dose-dependent fashion, this effect being enhanced by increasing pH of the medium from 7.0 to 7.8. The hypothesis that this Na+ effect was mediated by alkalinization of the acidocalcisomes via a Na+/H+ antiporter was supported by experiments showing that Na+ promotes release of Acridine Orange previously accumulated in these vacuoles. This putative antiporter did not transport Li+ and was not sensitive to the amiloride analogue 5-(N-ethyl-N-isopropyl)amiloride. Addition of the Na+/H+ ionophore monensin to intact cells loaded with fura 2, in the nominal absence of extracellular Ca2+ to preclude Ca2+ entry, was followed by an increase in cytosolic Ca2+ concentration ([Ca2+]i), which was more accentuated in the presence of extracellular Na+. An increase in intracellular pH (pHi) of BCECF-loaded cells was detected after addition of monensin in the presence of extracellular Na+, whereas a dramatic decrease in pHi was detected in its absence, thus indicating the presence of a significant amount of releasable protons in the acidic compartments. These results are consistent with the presence of a Na+/H+ antiporter in the acidocalcisomes that could be involved in the regulation of pH1 and [Ca2+]1 in these parasites. | lld:pubmed |
| pubmed-article:8670117 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8670117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8670117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8670117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8670117 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8670117 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8670117 | pubmed:author | pubmed-author:DocampoRR | lld:pubmed |
| pubmed-article:8670117 | pubmed:author | pubmed-author:VercesiA EAE | lld:pubmed |
| pubmed-article:8670117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8670117 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8670117 | pubmed:volume | 315 ( Pt 1) | lld:pubmed |
| pubmed-article:8670117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8670117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8670117 | pubmed:pagination | 265-70 | lld:pubmed |
| pubmed-article:8670117 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:meshHeading | pubmed-meshheading:8670117-... | lld:pubmed |
| pubmed-article:8670117 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8670117 | pubmed:articleTitle | Sodium-proton exchange stimulates Ca2+ release from acidocalcisomes of Trypanosoma brucei. | lld:pubmed |
| pubmed-article:8670117 | pubmed:affiliation | Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 71801, U.S.A. | lld:pubmed |
| pubmed-article:8670117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8670117 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8670117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8670117 | lld:pubmed |
