| pubmed-article:8668347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8668347 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:8668347 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8668347 | lifeskim:mentions | umls-concept:C0026575 | lld:lifeskim |
| pubmed-article:8668347 | lifeskim:mentions | umls-concept:C1160520 | lld:lifeskim |
| pubmed-article:8668347 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8668347 | pubmed:dateCreated | 1996-8-8 | lld:pubmed |
| pubmed-article:8668347 | pubmed:abstractText | The function of the Xenopus c-mos proto-oncogene product (Mos(xe)) has been investigated during oocyte maturation. Experiments with a new antibody able to immunoblot Mos(xe) demonstrated the time course of MAP kinase (MAP K) activation in oocytes paralleled Mos(xe) accumulation, and in activated eggs the deactivation of MAP K paralleled the degradation of Mos(xe). Ablation of Mos synthesis by microinjection of antisense oligodeoxynucleotides abolished activation of MAP K by progesterone, but microinjection of GST-Mos fully restored both MAP K activation and germinal vesicle breakdown (GVBD). The Mos(xe) level at metaphase of Meiosis I (MI) was 2 - 3-fold less than that at metaphase of Meiosis II (MII), but MAP K activation was maximal at metaphase in both MI and MII. In the transition between MI and MII, both cyclin B and Mos(xe) levels rapidly declined in the presence of cycloheximide and injection of exogenous GST-Mos(xe) did not prevent degradation of either protein, although MAP K was activated. Microinjection of GST-Mos(xe) into oocytes was able to activate MAP K before GVBD and H1 kinase activation, and microinjection of constitutively-activated thiophosphorylated MAP K induced de novo synthesis of Mos(xe) before H1 kinase activation, suggesting the existence of a positive feedback loop between MAP K and Mos(xe) accumulation. | lld:pubmed |
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| pubmed-article:8668347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8668347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8668347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8668347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8668347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8668347 | pubmed:month | May | lld:pubmed |
| pubmed-article:8668347 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:IzumiTT | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:MallerJ LJL | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:LiuW FWF | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:HaccardOO | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:LewellynA LAL | lld:pubmed |
| pubmed-article:8668347 | pubmed:author | pubmed-author:LattesB GBG | lld:pubmed |
| pubmed-article:8668347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8668347 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8668347 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8668347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8668347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8668347 | pubmed:pagination | 2203-11 | lld:pubmed |
| pubmed-article:8668347 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8668347 | pubmed:meshHeading | pubmed-meshheading:8668347-... | lld:pubmed |
| pubmed-article:8668347 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8668347 | pubmed:articleTitle | Mos proto-oncogene function during oocyte maturation in Xenopus. | lld:pubmed |
| pubmed-article:8668347 | pubmed:affiliation | Howard Hughes Medical Institute, University of Colorado School of Medicine, Denver, 80262, USA. | lld:pubmed |
| pubmed-article:8668347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8668347 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8668347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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