| pubmed-article:8668124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C0012524 | lld:lifeskim |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:8668124 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:8668124 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8668124 | pubmed:dateCreated | 1996-8-5 | lld:pubmed |
| pubmed-article:8668124 | pubmed:abstractText | NIN1 is an essential gene for growth of the yeast Saccharomyces cerevisiae and was recently found to encode a component of the regulatory subunit of the 26S proteasome. The nin1-1 mutant is temperature sensitive and its main defect is in G1/S progression and G2/M progression at non-permissive temperatures. One of the two multicopy suppressors of nin1-1, SUN2 (SUppressor of Nin1-1), was found to encode a protein of 523 amino acids whose sequence is similar to those of Drosophila melanogaster diphenol oxidase A2 and the mouse mast-cell Tum(-) transplantation antigen, P91A. The C-terminal half of Sun2p was found to be functional as Sun2p at 25 degrees C, 30 degrees C, and 34 degrees C but not at 37 degrees C. The open reading frame (ORF) of the Drosophila diphenol oxidase A2 gene (Dox-A2) was obtained from a lambda phage cDNA library using the polymerase chain reaction technique. The Dox-A2 ORF driven by the TDH3 promoter complemented the phenotype of a strain deleted for sun2. This Dox-A2-dependent strain was temperature sensitive and accumulated dumb-bell-shaped cells, with an undivided nucleus at the isthmus, after temperature upshift. This morphology is similar to that of nin1-1 cells kept at a restrictive temperature. These results suggest that SUN2 is a functional counterpart of Dox-A2 and that these genes play a pivotal role in the cell cycle in each organism. | lld:pubmed |
| pubmed-article:8668124 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8668124 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8668124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8668124 | pubmed:month | May | lld:pubmed |
| pubmed-article:8668124 | pubmed:issn | 0026-8925 | lld:pubmed |
| pubmed-article:8668124 | pubmed:author | pubmed-author:KawamuraMM | lld:pubmed |
| pubmed-article:8668124 | pubmed:author | pubmed-author:Toh-eAA | lld:pubmed |
| pubmed-article:8668124 | pubmed:author | pubmed-author:TakeuchiJJ | lld:pubmed |
| pubmed-article:8668124 | pubmed:author | pubmed-author:KominamiKK | lld:pubmed |
| pubmed-article:8668124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8668124 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:8668124 | pubmed:volume | 251 | lld:pubmed |
| pubmed-article:8668124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8668124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8668124 | pubmed:pagination | 146-52 | lld:pubmed |
| pubmed-article:8668124 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8668124 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8668124 | pubmed:articleTitle | A multicopy suppressor of nin1-1 of the yeast Saccharomyces cerevisiae is a counterpart of the Drosophila melanogaster diphenol oxidase A2 gene, Dox-A2. | lld:pubmed |
| pubmed-article:8668124 | pubmed:affiliation | Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:8668124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8668124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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