| pubmed-article:8666940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8666940 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:8666940 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8666940 | pubmed:dateCreated | 1996-8-5 | lld:pubmed |
| pubmed-article:8666940 | pubmed:abstractText | The hypothesis that the type II receptor (RII) acts as a decoy for interleukin-1 (IL-1) was tested by gene transfer in cells expressing only the type I receptor (8387 fibroblasts). RII-transfected cells showed defective responsiveness to IL-1 in terms of NFkappaB activation, cytokine gene expression and production. Blocking monoclonal antibodies against RII restored the capacity of RII-transfected cells to respond to IL-1 beta. Hence defective IL-1 responsiveness of RII-transfected cells requires surface expression of the molecule. RII-transfected cells showed normal responsiveness to TNF, which shares functional properties and elements in the signal transduction pathway with IL-1. Cells transfected with a deletion mutant of RII missing 26 of 29 amino acids of the cytoplasmic portion of the molecule showed impaired responsiveness to IL-2. Cells transfected with full-length or the cytoplasmic deletion mutant of RII released copious amounts of RII in the supernatant. However, transfected cells showed defective responsiveness to brief exposure to IL-1, in the absence of measurable released RII. These results indicate that impairment of the responsiveness to IL-1 following RII gene transfer was dependent upon surface expression of the molecule, specific for IL-1 and unaffected by truncation of the cytoplasmic portion. Thus, the type II "receptor" is a decoy surface molecule, regulated by antiinflammatory signals, whose only known function is to capture and block IL-1. | lld:pubmed |
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| pubmed-article:8666940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8666940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8666940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8666940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8666940 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8666940 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:MantovaniAA | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:SironiMM | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:DowerS KSK | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:MuziiGG | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:SICC | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:SimsJ EJE | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:ColottaFF | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:IntronaMM | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:MatteucciCC | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:OrlandoSS | lld:pubmed |
| pubmed-article:8666940 | pubmed:author | pubmed-author:Penton-RolGG | lld:pubmed |
| pubmed-article:8666940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8666940 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8666940 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:8666940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8666940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8666940 | pubmed:pagination | 1841-50 | lld:pubmed |
| pubmed-article:8666940 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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