| pubmed-article:8666427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8666427 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:8666427 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8666427 | pubmed:dateCreated | 1996-8-7 | lld:pubmed |
| pubmed-article:8666427 | pubmed:abstractText | To verify the hypothesis that eosinophils produce interleukin-2 (IL-2), a cytokine essential for lymphocyte activation, the expression of IL-2 was examined in peripheral blood eosinophils obtained from normal, atopic, asthmatic and hypereosinophilic subjects. Purified blood cell preparations were > 95% eosinophils, the remaining cells being neutrophils. Based on morphological observations and on CD3 expression, no lymphocytes were detected in these eosinophil preparations. The expression of IL-2 mRNA was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in total RNA extracted from purified eosinophils stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF), with or without calcium ionophore (A23187). In-cell RT-PCR combined with in situ hybridization further confirmed that it was the eosinophils that expressed IL-2 mRNA. Moreover, in this experiment IL-2 mRNA expression increased upon costimulation with A23187 and GM-CSF suggesting that a steady-state level of IL-2 mRNA was inducible. Finally, IL-2 was detected in purified eosinophils by immunochemistry. These data, obtained by different techniques, demonstrate that eosinophils can express IL-2. An IL-2-mediated eosinophil-lymphocyte interaction could contribute to the chronic state of cell activation in inflamed tissues where these cells are implicated. | lld:pubmed |
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| pubmed-article:8666427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8666427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666427 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8666427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8666427 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8666427 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:PelletierGG | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:AudetteMM | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:BouletL PLP | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:LavioletteMM | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:BosséMM | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:ChuH WHW | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:FerlandCC | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:DakhamaAA | lld:pubmed |
| pubmed-article:8666427 | pubmed:author | pubmed-author:LavigneSS | lld:pubmed |
| pubmed-article:8666427 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8666427 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:8666427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8666427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8666427 | pubmed:pagination | 149-54 | lld:pubmed |
| pubmed-article:8666427 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8666427 | pubmed:meshHeading | pubmed-meshheading:8666427-... | lld:pubmed |
| pubmed-article:8666427 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8666427 | pubmed:articleTitle | Gene expression of interleukin-2 in purified human peripheral blood eosinophils. | lld:pubmed |
| pubmed-article:8666427 | pubmed:affiliation | Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Canada. | lld:pubmed |
| pubmed-article:8666427 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8666427 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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