| pubmed-article:8666216 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C0035078 | lld:lifeskim |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C0232804 | lld:lifeskim |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C1864785 | lld:lifeskim |
| pubmed-article:8666216 | lifeskim:mentions | umls-concept:C0016365 | lld:lifeskim |
| pubmed-article:8666216 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8666216 | pubmed:dateCreated | 1996-8-8 | lld:pubmed |
| pubmed-article:8666216 | pubmed:abstractText | Nine depressed patients with normal kidney function and seven depressed patients with renal failure undergoing hemodialysis were treated with open-label fluoxetine 20 mg/day in an 8-week study. The study was designed to evaluate the pharmacokinetics of fluoxetine during repeated administration and to acquire preliminary data regarding the effectiveness of this antidepressant in a population undergoing hemodialysis. Six patients in each group completed the study. Of these, five patients undergoing hemodialysis and five patients with normal renal function experienced moderate to marked improvement in their depression. Side effects were equal and minor in both groups, indicating that fluoxetine is safe in patients with renal impairment. The mean +/- standard deviation steady-state plasma concentrations of the sum of fluoxetine plus its metabolite norfluoxetine for patients completing 8 weeks (N = 6, both groups) were comparable for the patients undergoing hemodialysis (253 +/- 61 ng/ml) and those with normal kidney function (218 +/- 122 ng/ml; t = 1.5, df = 70, p > 0.13). These data suggest that the efficacy of fluoxetine in patients with renal failure undergoing hemodialysis is comparable to that in patients with normal kidney function. These data further suggest that renal failure and the process of hemodialysis do not materially alter the pharmacokinetics of fluoxetine or its major metabolite norfluoxetine. | lld:pubmed |
| pubmed-article:8666216 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8666216 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666216 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8666216 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666216 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8666216 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8666216 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8666216 | pubmed:issn | 0163-8343 | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:SolomonR JRJ | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:LevyN BNB | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:BlumenfieldMM | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:ToddRR | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:GoodmanAA | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:DubeyA KAK | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:BeasleyC... | lld:pubmed |
| pubmed-article:8666216 | pubmed:author | pubmed-author:BergstromR... | lld:pubmed |
| pubmed-article:8666216 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8666216 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:8666216 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8666216 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8666216 | pubmed:pagination | 8-13 | lld:pubmed |
| pubmed-article:8666216 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8666216 | pubmed:meshHeading | pubmed-meshheading:8666216-... | lld:pubmed |
| pubmed-article:8666216 | pubmed:meshHeading | pubmed-meshheading:8666216-... | lld:pubmed |
| pubmed-article:8666216 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8666216 | pubmed:articleTitle | Fluoxetine in depressed patients with renal failure and in depressed patients with normal kidney function. | lld:pubmed |
| pubmed-article:8666216 | pubmed:affiliation | Department of Psychiatry and Medicine, Westchester County Medical Center, Valhalla, NY, USA. | lld:pubmed |
| pubmed-article:8666216 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8666216 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666216 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8666216 | lld:pubmed |
