27-hydroxylated low density lipoprotein (LDL) cholesterol can be converted to 7alpha,27-dihydroxy-4-cholesten-3-one (cytosterone) before suppressing cholesterol production in normal human fibroblasts. Evidence that an altered metabolism of ldl cholesterol can underlie a defective feedback control in malignant cells.
Source:http://linkedlifedata.com/resource/pubmed/id/8662693
J. Biol. Chem.
1996
May
31
271
22
12724-36
