| pubmed-article:8655997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:8655997 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:8655997 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8655997 | pubmed:dateCreated | 1996-7-31 | lld:pubmed |
| pubmed-article:8655997 | pubmed:abstractText | The aim of this study was to investigate the extent of lysis mediated by cytotoxic T lymphocytes (CTL) directed against human immunodeficiency virus (HIV) type 1 gag protein and envelope glycoprotein in peripheral blood mononuclear cells (PBMC) from HIV-1-infected subjects and to compare it with nonspecific envelope glycoprotein-directed cytotoxicity involving CD4 T cells. Most seropositive subjects exhibited antigen-specific cytotoxicity directed at one or both viral antigens in unstimulated or in vitro-stimulated PBMC (or both) mediated by CD8 T cells. In addition, all donors, including seronegative control persons, exhibited nonspecific calcium-independent cytotoxicity involving CD4 T cells and envelope glycoprotein-expressing cells. No calcium-dependent, antigen-specific CD4 T cell-mediated cytolysis was detected. In seropositive subjects, the vigor of nonspecific cytotoxicity was comparable to lysis by antigen-specific CD8 CTL and suggests that it may contribute to lysis of HIV-infected cells in vitro and in vivo. | lld:pubmed |
| pubmed-article:8655997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8655997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8655997 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8655997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8655997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8655997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8655997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8655997 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8655997 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:8655997 | pubmed:author | pubmed-author:JassoyCC | lld:pubmed |
| pubmed-article:8655997 | pubmed:author | pubmed-author:KlinkerHH | lld:pubmed |
| pubmed-article:8655997 | pubmed:author | pubmed-author:HeinkeleinMM | lld:pubmed |
| pubmed-article:8655997 | pubmed:author | pubmed-author:Euler-KönigII | lld:pubmed |
| pubmed-article:8655997 | pubmed:author | pubmed-author:Rückle-LanzHH | lld:pubmed |
| pubmed-article:8655997 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8655997 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:8655997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8655997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8655997 | pubmed:pagination | 209-13 | lld:pubmed |
| pubmed-article:8655997 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8655997 | pubmed:meshHeading | pubmed-meshheading:8655997-... | lld:pubmed |
| pubmed-article:8655997 | pubmed:meshHeading | pubmed-meshheading:8655997-... | lld:pubmed |
| pubmed-article:8655997 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8655997 | pubmed:articleTitle | Lysis of human immunodeficiency virus type 1 antigen-expressing cells by CD4 and CD8 T cells ex vivo. | lld:pubmed |
| pubmed-article:8655997 | pubmed:affiliation | Department of Internal Medicine, and Medical Policlinic, University of Würzburg, Germany. | lld:pubmed |
| pubmed-article:8655997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8655997 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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