| pubmed-article:8650156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C0813983 | lld:lifeskim |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:8650156 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:8650156 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8650156 | pubmed:dateCreated | 1996-7-25 | lld:pubmed |
| pubmed-article:8650156 | pubmed:abstractText | Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of murine erythroleukemia (MEL) cells and a wide variety of other transformed cells. HMBA has been shown to induce differentiation of neoplastic cells in patients, but is not an adequate therapeutic agent because of dose-limiting toxicity. We report on a group of three potent second generation hybrid polar compounds, diethyl bis-(pentamethylene-N,N-dimethylcarboxamide) malonate (EMBA), suberoylanilide hydroxamic acid (SAHA), and m-carboxycinnamic acid bis-hydroxamide (CBHA) with optimal concentrations for inducing MEL cells of 0.4 mM, 2 microM, and 4 microM, respectively, compared to 5 mM for HMBA. All three agents induce accumulation of underphosphorylated pRB; increased levels of p2l protein, a prolongation of the initial G1 phase of the cell cycle; and accumulation of hemoglobin. However, based upon their effective concentrations, the cross-resistance or sensitivity of an HMBA-resistant MEL cell variant, and differences in c-myb expression during induction, these differentiation-inducing hybrid polar compounds can be grouped into two subsets, HMBA/EMBA and SAHA/CBHA. This classification may prove of value in selecting and planning prospective preclinical and clinical studies toward the treatment of cancer by differentiation therapy. | lld:pubmed |
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| pubmed-article:8650156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8650156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8650156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8650156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8650156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8650156 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8650156 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:MarksP APA | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:RifkindR ARA | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:BreslowRR | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:MergerRR | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:NgoLL | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:RichonV MVM | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:WebbYY | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:JursicBB | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:CivoliFF | lld:pubmed |
| pubmed-article:8650156 | pubmed:author | pubmed-author:SheppardTT | lld:pubmed |
| pubmed-article:8650156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8650156 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:8650156 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8650156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8650156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8650156 | pubmed:pagination | 5705-8 | lld:pubmed |
| pubmed-article:8650156 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8650156 | pubmed:meshHeading | pubmed-meshheading:8650156-... | lld:pubmed |
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| pubmed-article:8650156 | pubmed:meshHeading | pubmed-meshheading:8650156-... | lld:pubmed |
| pubmed-article:8650156 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8650156 | pubmed:articleTitle | Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. | lld:pubmed |
| pubmed-article:8650156 | pubmed:affiliation | Program of Cell Biology and Genetics, DeWitt Wallace Research Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:8650156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8650156 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8650156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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